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142360

4-Benzylpiperidine

99%

Synonym(s):

Phenyl(4-piperidyl)methane

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About This Item

Empirical Formula (Hill Notation):
C12H17N
CAS Number:
31252-42-3
Molecular Weight:
175.27
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24848521
EC Number:
250-535-0
Beilstein/REAXYS Number:
132339
MDL number:
MFCD00006006
Assay:
99%
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description

Drug Control: Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet

Quality Level

100

assay

99%

drug control

Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet

refractive index

n20/D 1.537 (lit.)

bp

279 °C (lit.)

mp

6-7 °C (lit.)

density

0.997 g/mL at 25 °C (lit.)

functional group

phenyl

SMILES string

C1CC(CCN1)Cc2ccccc2

InChI

1S/C12H17N/c1-2-4-11(5-3-1)10-12-6-8-13-9-7-12/h1-5,12-13H,6-10H2

InChI key

ABGXADJDTPFFSZ-UHFFFAOYSA-N

Gene Information

rat ... Htr2a(29595), Htr2c(25187)

General description

4-Benzylpiperidine is dopamine-selective releaser. It is a potential candidate for treatments for cocaine dependence.

Application

4-Benzylpiperidine was used to study the metabolism of 1,3-butadiene and its oxidized metabolites in perfused livers of male B6C3F1 mice and Sprague-Dawley rats.
Reactant for synthesis of:
  • Antiproliferatives
  • GABA uptake inhibitors
  • Pyridines
  • Histamine H3 antagonists
  • Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer′s and neuronal vascular diseases
  • Antiserotoninergic, antiplatelet, hemorheologic, antiarrythmic and antioxidant molecules via nucleophilic substitution

Biochem/physiol Actions

4-Benzylpiperidine inhibits the activity of rat brain monoamine oxidase-A and -B.

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

233.6 °F - closed cup

flash_point_c

112 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
12903TH
S43132
14111HH
08921CH
05316CH

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Johannes G Filser et al.
Toxicological sciences : an official journal of the Society of Toxicology, 114(1), 25-37 (2009-12-17)
The industrial chemical 1,3-butadiene (BD) is a potent carcinogen in mice and a weak one in rats. This difference is generally related to species-specific burdens by the metabolites 1,2-epoxy-3-butene (EB), 1,2:3,4-diepoxybutane (DEB), and 3,4-epoxy-1,2-butanediol (EBD), which are all formed in
Y Arai et al.
Neuroscience letters, 70(2), 255-260 (1986-10-08)
Inhibitory effects of some MPTP and MPP+ analogues on rat brain MAO activity were studied to further clarify the structure-activity relationships of MPTP neurotoxicity. Of the analogues tested, 4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine (CPTP), 4-(4-chlorobenzyl)-pyridine (CBP), 4-benzylpyridine (BPY) and 4-benzylpiperidine (BPIP) dose-dependently inhibited both
Sindhu S Ganti et al.
International journal of pharmaceutics, 550(1-2), 71-78 (2018-08-21)
The objective of our study was to develop a transdermal patch of 4-benzylpiperidine and to evaluate its in vitro transdermal permeation profile. Appropriate pressure sensitive adhesives and additives were selected based on solubility and slide crystallization studies. Release liners and
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Global Trade Item Number

SKUGTIN
142360-25G04061837775369