143413
1,3-Diaminoguanidine monohydrochloride
98%
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About This Item
Linear Formula:
H2NNHC(=NH)NHNH2·HCl
CAS Number:
Molecular Weight:
125.56
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
252-854-0
MDL number:
InChI key
HAZRIBSLCUYMQP-UHFFFAOYSA-N
InChI
1S/CH7N5.ClH/c2-1(5-3)6-4;/h3-4H2,(H3,2,5,6);1H
SMILES string
Cl.NNC(=N)NN
assay
98%
mp
180-182 °C (dec.) (lit.)
solubility
water: soluble 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
General description
1,3-Diaminoguanidine monohydrochloride undergoes condensation reaction with:
- 4-isothiocyanato-4-methylpentane-2-one to yield condensed pyrimidines
- various aldehydes and ketones to yield bis guanidine derivatives
Other Notes
Contains sodium chloride
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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K Kumari et al.
Diabetes, 40(8), 1079-1084 (1991-08-01)
Mono- and diaminoguanidine inhibited ambient glucose-induced glycosylated end product formation of albumin and collagen 125I-labeled albumin covalent binding in vitro. Diaminoguanidine was a stronger inhibitor than monoaminoguanidine. These compounds also inhibited rat eye lens aldose reductase activity in vitro noncompetitively
D Dvornik et al.
Journal of diabetes and its complications, 10(1), 23-30 (1996-01-01)
Aminoguanidine, nucleophilic hydrazine derivative, has been shown to inhibit diamine oxidase, the formation of advanced glycation endproducts, nitric oxide synthase, and catalase. Prompted by the reports that aminoguanidine also inhibits aldose reductase (AR), we have investigated the effect of aminoguanidine
Synthesis of biologically active novel bis Schiff bases, bis hydrazone and bis guanidine derivatives.
Sondhi SM, et al.
Indian J. Chem. B, 48(8), 1128-1128 (2009)
María Paula Campestre et al.
Journal of plant physiology, 168(11), 1234-1240 (2011-02-18)
The possible relationship between polyamine catabolism mediated by copper-containing amine oxidase and the elongation of soybean hypocotyls from plants exposed to NaCl has been studied. Salt treatment reduced values of all hypocotyl growth parameters. In vitro, copper-containing amine oxidase activity
Naoyoshi Ishikawa et al.
Kidney international, 63(1), 331-339 (2002-12-11)
Reactive carbonyl compounds (RCOs) present in peritoneal dialysis (PD) fluid have been incriminated in the progressive deterioration of the peritoneal membrane in long-term PD patients. They are initially present in fresh conventional heat-sterilized glucose PD fluid and are supplemented during
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