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15149

N,N-Bis(phosphonomethyl)glycine

≥98.0% (T)

Synonym(s):

N-(Carboxymethyl)iminodi(methylphosphinic acid), Glyphosine

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About This Item

Empirical Formula (Hill Notation):
C4H11NO8P2
CAS Number:
Molecular Weight:
263.08
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
219-468-4
Beilstein/REAXYS Number:
1884944
MDL number:
Assay:
≥98.0% (T)
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Quality Segment

assay

≥98.0% (T)

functional group

amine, carboxylic acid

SMILES string

O=P(CN(CP(O)(O)=O)CC(O)=O)(O)O

InChI

1S/C4H11NO8P2/c6-4(7)1-5(2-14(8,9)10)3-15(11,12)13/h1-3H2,(H,6,7)(H2,8,9,10)(H2,11,12,13)

InChI key

OXHDYFKENBXUEM-UHFFFAOYSA-N

General description

N,N-Bis(phosphonomethyl)glycine was present in the ligand bound to human apotransferrin.

Application

Application: Complexing agent; pK-values: pK1: ·2, pK2: 2.0, pK3: 5.20, pK4: 6.77, pK5: 10.89

Anti-diabetic; delay onset of diabetes in non-obese NOD mice

Glyphosine binds to a pocket of MHC class II molecules I-Ag7 and DQ8, and modify T cell responses to the autoantigenic insulin B chain fragment 9–23 (B:9–23) peptide. Glyphosine stimulate IL-10 production and delay onset of diabetes in non-obese NOD mice.†

Biochem/physiol Actions

Anti-diabetic; delay onset of diabetes in non-obese NOD mice


pictograms

Corrosion

signalword

Danger

hcodes

Hazard Classifications

Eye Dam. 1

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves



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