151564
5-Hydroxydopamine hydrochloride
98%
Synonym(s):
3,4,5-Trihydroxyphenethylamine hydrochloride
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About This Item
Linear Formula:
(HO)3C6H2CH2CH2NH2·HCl
CAS Number:
Molecular Weight:
205.64
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
227-223-8
MDL number:
Assay:
98%
Form:
powder
InChI key
WSZSSLCEWCKAKU-UHFFFAOYSA-N
InChI
1S/C8H11NO3.ClH/c9-2-1-5-3-6(10)8(12)7(11)4-5;/h3-4,10-12H,1-2,9H2;1H
SMILES string
Cl.NCCc1cc(O)c(O)c(O)c1
assay
98%
form
powder
mp
218-220 °C (lit.)
functional group
amine
Application
5-Hydroxydopamine hydrochloride was used in the preparation of hydrogen peroxide, superoxide radical and hydroxyl radical.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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F Neff et al.
Annals of the New York Academy of Sciences, 973, 70-74 (2002-12-18)
We show that the glial cell line-derived neurotrophic factor (GDNF) activates the PI3K/Akt-signaling pathway in human neuroblastoma cells that express functional Ret-receptor complexes. Consistent with this finding we show PI3K-dependent Bad-inactivation by binding to 14-3-3 proteins in response to GDNF.
K S Lu et al.
Archives of histology and cytology, 55(1), 57-65 (1992-03-01)
The ultrastructure of the Type I cells in paraganglia of rat recurrent laryngeal nerve (RLN) was studied after the administration of 5-hydroxydopamine (5-OHDA) and 6-hydroxydopamine (6-OHDA). Normal Type I cells of RLN-paraganglia contained abundant organelles and their cytoplasm was characterized
James P Hayes et al.
Toxicology letters, 128(1-3), 197-206 (2002-03-01)
The neurotoxin 6-hydroxydopamine (6-OHDA) oxidised sulphydryl groups in glyceraldenyde-3-phosphate dehydrogenase (GAPDH) with loss of the dehydrogenase activity of the enzyme. 5-Hydroxydopamine behaved similarly at higher concentrations. This oxidation was accompanied by a transient rise in the acyl phosphatase (non-phosphorylating) activity
Jose A Rodríguez-Gómez et al.
Stem cells (Dayton, Ohio), 25(4), 918-928 (2006-12-16)
The derivation of dopamine neurons is one of the best examples of the clinical potential of embryonic stem (ES) cells, but the long-term function of the grafted neurons has not been established. Here, we show that, after transplantation into an
E Kienzl et al.
Life sciences, 65(18-19), 1973-1976 (1999-11-27)
The mechanisms leading to degeneration of melanized dopaminergic neurons in the brain stem, and particularly in the substantia nigra zona compacta (SNZC) in patients with Parkinson's disease (PD) are still unknown. Demonstration of increased iron Fe(III) in SNZC of PD
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