151564
5-Hydroxydopamine hydrochloride
98%
Synonym(s):
3,4,5-Trihydroxyphenethylamine hydrochloride
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About This Item
Linear Formula:
(HO)3C6H2CH2CH2NH2·HCl
CAS Number:
Molecular Weight:
205.64
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Assay
98%
form
powder
mp
218-220 °C (lit.)
functional group
amine
SMILES string
Cl.NCCc1cc(O)c(O)c(O)c1
InChI
1S/C8H11NO3.ClH/c9-2-1-5-3-6(10)8(12)7(11)4-5;/h3-4,10-12H,1-2,9H2;1H
InChI key
WSZSSLCEWCKAKU-UHFFFAOYSA-N
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Application
5-Hydroxydopamine hydrochloride was used in the preparation of hydrogen peroxide, superoxide radical and hydroxyl radical.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Jose A Rodríguez-Gómez et al.
Stem cells (Dayton, Ohio), 25(4), 918-928 (2006-12-16)
The derivation of dopamine neurons is one of the best examples of the clinical potential of embryonic stem (ES) cells, but the long-term function of the grafted neurons has not been established. Here, we show that, after transplantation into an
F Neff et al.
Annals of the New York Academy of Sciences, 973, 70-74 (2002-12-18)
We show that the glial cell line-derived neurotrophic factor (GDNF) activates the PI3K/Akt-signaling pathway in human neuroblastoma cells that express functional Ret-receptor complexes. Consistent with this finding we show PI3K-dependent Bad-inactivation by binding to 14-3-3 proteins in response to GDNF.
K S Lu et al.
Archives of histology and cytology, 55(1), 57-65 (1992-03-01)
The ultrastructure of the Type I cells in paraganglia of rat recurrent laryngeal nerve (RLN) was studied after the administration of 5-hydroxydopamine (5-OHDA) and 6-hydroxydopamine (6-OHDA). Normal Type I cells of RLN-paraganglia contained abundant organelles and their cytoplasm was characterized
J C Linder et al.
Neurochemistry international, 26(2), 195-202 (1995-02-01)
The dopaminergic projection from the substantia nigra to the neostriatum is vulnerable to several neurotoxins including 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), amphetamine, and 5-hydroxydopamine. We have treated rats or mice with these agents and examined various regions of their brains with a combination
F Vandenabeele et al.
Archives of histology and cytology, 64(1), 1-16 (2001-04-20)
Ultrastructural studies of the synovial membrane were performed on tissue samples obtained from the human lumbar facet joint. Ultrastructural changes in synoviocytes were studied after loading synovial samples with 5-hydroxydopamine (5-OHDA) in an oxygenated Krebs' solution, prior to fixation. Synoviocytes
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