152935
1-Piperidinepropanol
97%
Synonym(s):
1-(3-Hydroxypropyl)piperidine
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About This Item
Empirical Formula (Hill Notation):
C8H17NO
CAS Number:
Molecular Weight:
143.23
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
203-216-5
MDL number:
Assay:
97%
Form:
liquid
InChI key
PLRXAFVBCHEMGD-UHFFFAOYSA-N
InChI
1S/C8H17NO/c10-8-4-7-9-5-2-1-3-6-9/h10H,1-8H2
SMILES string
OCCCN1CCCCC1
assay
97%
form
liquid
refractive index
n20/D 1.4775 (lit.)
bp
94-95 °C/0.5 mmHg (lit.)
density
0.944 g/mL at 25 °C (lit.)
functional group
hydroxyl
Application
1-Piperidinepropanol was used to prepare isothiourea.
Reactant in:
Mitsunobu reaction of intramolecular nitrile oxide-alkene cycloadditions
Suzuki-coupling
Reactant for synthesis of:
Histamine H3 receptor antagonists
Protein lysine methyltransferase G9a inhibitors
Serotonin-4 receptors antagonists
Checkpoint kinase Chk2 inhibitors
Mitsunobu reaction of intramolecular nitrile oxide-alkene cycloadditions
Suzuki-coupling
Reactant for synthesis of:
Histamine H3 receptor antagonists
Protein lysine methyltransferase G9a inhibitors
Serotonin-4 receptors antagonists
Checkpoint kinase Chk2 inhibitors
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
208.0 °F - closed cup
flash_point_c
97.8 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Shinya Harusawa et al.
Bioorganic & medicinal chemistry letters, 23(23), 6415-6420 (2013-10-22)
S-Alkyl-N-alkylisothiourea compounds containing various cyclic amines were synthesized in the search for novel nonimidazole histamine H3 receptor (H3R) antagonists. Among them, four N-alkyl S-[3-(piperidin-1-yl)propyl]isothioureas 18, 19, 22, and 23 were found to exhibit potent and selective H3R antagonistic activities against
Joseph A McQuail et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(50), 12537-12548 (2016-11-04)
Working memory, the ability to temporarily maintain representational knowledge, is a foundational cognitive process that can become compromised in aging and neuropsychiatric disease. NMDA receptor (NMDAR) activation in prefrontal cortex (PFC) is necessary for the pyramidal neuron activity believed to
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