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154563

Sigma-Aldrich

Tris(hydroxymethyl)aminomethane

ultrapure grade, ≥99.9%

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Synonym(s):
2-Amino-2-(hydroxymethyl)-1,3-propanediol, THAM, Tris base, Trometamol
Linear Formula:
NH2C(CH2OH)3
CAS Number:
77-86-1
Molecular Weight:
121.14
Beilstein:
741883
EC Number:
201-064-4
MDL number:
MFCD00004679
PubChem Substance ID:
329750892

grade

ultrapure grade

Assay

≥99.9%

form

solid

useful pH range

7-9

pKa (25 °C)

8.1

bp

219-220 °C/10 mmHg (lit.)

mp

167-172 °C (lit.)

solubility

water: 0.66 g/mL, clear, colorless

SMILES string

NC(CO)(CO)CO

InChI

1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2

InChI key

LENZDBCJOHFCAS-UHFFFAOYSA-N

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Application

Buffer and primary pH standard. pKa=8.3 at 20°C. Auxiliary material in pharmaceutical science.

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What does the "ultrapure grade" in the description of Product 154563, Tris(hydroxymethyl)aminomethane, indicate?

    This material has been specifically purified to have the lowest heavy metals and iron content.

  4. What solvents can be used to dissolve Product T54563, Trometamol?

    According to the chemicals encyclopedia published by the Royal Society of Chemistry (which we also offer as Product No. Z705322), this material is expected to be soluble in water (550 mg/mL), ethylene glycol (79.1 mg/mL), methanol (26 mg/mL), anhydrous ethanol (14.6 mg/mL), 95% ethanol (22 mg/mL), dimethylformamide (14mg/mL) and acetone (2mg/mL) at room temperature.

  5. Where can I find more technical information on Product T54563, Trometamol, and other buffers?

    Please visit the Learning Center in our Buffer Explorer section of the website. There you will find helpful formulas, buffer calculator tools and other property information on our buffer products.

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Chem. Abstr., 121, 212675r-212675r (1994)
Chimica Oggi, 12, 24-24 (1994)
Aldrichimica Acta, 16, 35-35 (1983)
Sylvain Clède et al.
Chemical communications (Cambridge, England), 48(62), 7729-7731 (2012-06-29)
A rhenium tris-carbonyl derivative has been designed to couple infrared and luminescent detection in cells. Both spectroscopies are consistent with one another; they point out the reliability of the present SCoMPI (for Single Core Multimodal Probe for Imaging) for bimodal
Corey A Baron et al.
Magnetic resonance in medicine, 73(3), 1075-1084 (2014-04-12)
An acquisition method that does not increase scan time or specific absorption rate is investigated for reducing the deleterious effects of cerebrospinal fluid (CSF) partial volume effects on diffusion tensor imaging (DTI) tractography. It is based on using a shorter
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