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Merck
CN

15525

Boc-Tyr-OSu

≥99.0% (N)

Synonym(s):

Boc-L-tyrosine hydroxysuccinimide ester

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About This Item

Empirical Formula (Hill Notation):
C18H22N2O7
CAS Number:
20866-56-2
Molecular Weight:
378.38
PubChem Substance ID:
57647471
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
1557147
MDL number:
MFCD00037910

Key Documents

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SMILES string

CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)ON2C(=O)CCC2=O

InChI

1S/C18H22N2O7/c1-18(2,3)26-17(25)19-13(10-11-4-6-12(21)7-5-11)16(24)27-20-14(22)8-9-15(20)23/h4-7,13,21H,8-10H2,1-3H3,(H,19,25)/t13-/m0/s1

InChI key

NZUDTLHVKHXJJJ-ZDUSSCGKSA-N

assay

≥99.0% (N)

optical activity

[α]20/D −13±1°, c = 1% in dioxane

mp

~190 °C (dec.)

application(s)

peptide synthesis

storage temp.

−20°C

Other Notes

Reagent used in a rapid method for iodotyrosylation of peptides.; This method is equal to that of Bolton-Hunter but has the additional advantage that the derivatized peptide is readily deblocked to form a radiolabelled product with the same net charge as the starting material

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCBC5358V
BCBC5358
1368150
1408420
1406689

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Iodotyrosylation of peptides using tertiary-Butyloxycarbonyl-L-[125I]iodotyrosine N-hydroxysuccinimide ester.
R K Assoian et al.
Analytical biochemistry, 103(1), 70-76 (1980-03-15)
Patrick Neuberg et al.
International journal of pharmaceutics, 566, 141-148 (2019-05-28)
Small interfering RNAs (siRNAs) can down-regulate the expression of a target mRNA molecule in a sequence-specific manner, making them an attractive new class of drugs with broad potential for the treatment of diverse human diseases. Here, we report the synthesis

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