155306
N1-(6-Indazolyl)sulfanilamide
98%
Synonym(s):
6-Sulfanilamidoindazole
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About This Item
Empirical Formula (Hill Notation):
C13H12N4O2S
CAS Number:
Molecular Weight:
288.32
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
237-314-4
MDL number:
Assay:
98%
InChI key
RLNLIVBLEZDLMZ-UHFFFAOYSA-N
InChI
1S/C13H12N4O2S/c14-10-2-5-12(6-3-10)20(18,19)17-11-4-1-9-8-15-16-13(9)7-11/h1-8,17H,14H2,(H,15,16)
SMILES string
Nc1ccc(cc1)S(=O)(=O)Nc2ccc3cn[nH]c3c2
assay
98%
mp
193-195 °C (lit.)
General description
N1-(6-Indazolyl)sulfanilamide ( 6-Sulfanilamidoindazole) causes inflammation in the hind paws and ankles of older rat and sensitizes them to the lethal action of endotoxin.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Y Ohmachi et al.
Toxicologic pathology, 26(2), 262-270 (1998-04-21)
6-Sulfanilamidoindazole (6SAI) is a sulfonamide that induces acute, self-limiting arthritis in rats, and 6SAI-induced arthritis is thought to be a model for testing anti-inflammatory agents. In this study, in order to clarify the location of arthritis and relationships between arthritis
Y Ohmachi et al.
Histology and histopathology, 17(2), 437-444 (2002-04-19)
6-Sulfanilamidoindazole (6SAI) is known to induce not only an acute arthritis but also serositis and arteritis which resemble those induced by some vasodilators in rats. In this study, the recovery process of ankle lesions was examined histopathologically for up to
D Müller et al.
Agents and actions, 11(6-7), 736-740 (1981-12-01)
Hexobarbital sleeping time was prolonged and ethylmorphine N-demethylation was inhibited after a single dosage or seven administration of 6-SAI to old rats. These effects were independent of the development of arthritis. Changes in cytochrome P-450 concentration after 6-SAI treatment were
C O Samuelson et al.
Arthritis and rheumatism, 27(6), 689-693 (1984-06-01)
Inflammation induced by 6- sulfanilamidoindazole (6-SAI) in aged, outbred rats is predictably produced, but the pathogenesis is not understood. We demonstrate the variable resistance of 15 inbred rat strains to 6-SAI arthritis. Susceptibility to 6-SAI arthritis is not directly linked
M L Miller et al.
Circulatory shock, 18(1), 65-76 (1986-01-01)
6-Sulfanilamidoindazole (6-SAI) is a sulfonamide that induces inflammation in the ankles and hind paws of older rats and sensitizes the animals to the lethal actions of endotoxin. Sensitization is associated with reductions in plasma glucose concentration but not changes in
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