155306
N1-(6-Indazolyl)sulfanilamide
98%
Synonym(s):
6-Sulfanilamidoindazole
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About This Item
Empirical Formula (Hill Notation):
C13H12N4O2S
CAS Number:
Molecular Weight:
288.32
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Assay
98%
mp
193-195 °C (lit.)
SMILES string
Nc1ccc(cc1)S(=O)(=O)Nc2ccc3cn[nH]c3c2
InChI
1S/C13H12N4O2S/c14-10-2-5-12(6-3-10)20(18,19)17-11-4-1-9-8-15-16-13(9)7-11/h1-8,17H,14H2,(H,15,16)
InChI key
RLNLIVBLEZDLMZ-UHFFFAOYSA-N
General description
N1-(6-Indazolyl)sulfanilamide ( 6-Sulfanilamidoindazole) causes inflammation in the hind paws and ankles of older rat and sensitizes them to the lethal action of endotoxin.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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D D Blatter
Skeletal radiology, 16(3), 183-189 (1987-01-01)
Phosphorus-31 magnetic resonance spectroscopy (MRS) of the hind paws of rats was performed at 1.5 Tesla before and during the course of an experimentally-induced inflammatory arthritis. Arthritis was induced by daily subcutaneous administration of 6-sulfanilamidoindazole, an antibacterial sulfa known to
R Hirschelmann et al.
Agents and actions, 10(5), 431-434 (1980-11-01)
During 6-sulphanilamidoindazole (6-SAI) arthritis a significant increase of serum levels of the protease inhibitor alpha 2 macroglobulin (= alpha 2 acute phase globulin) and of Darcy's glycoprotein was found, whereas the content of female specific protein and of sulfhydryl groups
R Hirschelmann et al.
International journal of tissue reactions, 8(6), 469-473 (1986-01-01)
Arthritis induced by 6-sulphanilamidoindazole in older rats is not inhibited by a one-week treatment with superoxide dismutase, peroxidase or desferrioxamine. It is concluded that oxygen radicals hardly play a special part in the pathogenesis of 6-SAI arthritis. C-reactive protein and
Acute colchicine and vinblastine toxicity in 6-sulfanilamidoindazole-pretreated rats.
M L Miller et al.
Toxicology and applied pharmacology, 60(3), 500-508 (1981-09-30)
Yasushi Ohmachi et al.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 53(6), 447-452 (2002-04-03)
6-Sulfanilamidoindazole (6SAI) induces selflimiting arthritis in rats. Since close relationships exist between arthritis and endotoxin, four experiments were conducted to clarify the relationship between endotoxin and 6SAI-induced arthritis. Endotoxin levels in the plasma from the abdominal aorta and portal vein
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