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Merck
CN

15719

D-Mannitol

meets analytical specification of Ph. Eur., USP, FCC, E421, 98.0-101.5% (calc. to the dried substance, HPLC)

Synonym(s):

Mannite

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About This Item

Empirical Formula (Hill Notation):
C6H14O6
CAS Number:
69-65-8
Molecular Weight:
182.17
EC Number:
200-711-8
UNSPSC Code:
12352200
PubChem Substance ID:
22435040
Beilstein/REAXYS Number:
1721898
MDL number:
MFCD00064287

Key Documents

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assay

98-102% (calc. to dried substance), 98.0-101.5% (calc. to the dried substance, HPLC)

optical activity

[α]20/D +23 to +25°, c = 8% in Na2B4O7, [α]25/D +137 to +145

quality

meets analytical specification of Ph. Eur., USP, FCC, E421

impurities

acidity or alcalinity, complies, reducing sugars, complies, related substances, in accordance (HPLC), residual solvents, complies, sorbit (DC), complies, ≤0.007% free acid (as CH3COOH), ≤0.5% water (Karl Fischer)

ign. residue

≤0.1% (as SO4)

loss

≤0.3% loss on drying, 105 °C, 4 h

pH

5-7.5 (20 °C, 10%)

conductivity

20 μS/cm at 20 °C

mp

165-169 °C, 167-170 °C (lit.)

anion traces

chloride (Cl-): ≤50 mg/kg, sulfate (SO42-): ≤100 mg/kg

cation traces

As: ≤1 mg/kg, Cu: ≤10 mg/kg, Ni: ≤1 mg/kg, Zn: ≤10 mg/kg

suitability

complies for appearance of solution, passes test for identity (IR)

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1

InChI key

FBPFZTCFMRRESA-KVTDHHQDSA-N

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Biochem/physiol Actions

A sugar alcohol sweet tastant. Used in sweetness inhibition studies.

Storage Class

11 - Combustible Solids

ppe

Eyeshields, Gloves, type N95 (US)

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
70440
SZBB1500
SZBA2600
SZBB1500V
SZBA2600V

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Maria Badal Tejedor et al.
International journal of pharmaceutics, 486(1-2), 315-323 (2015-04-07)
Tablets are the most convenient form for drug administration. However, despite the ease of manufacturing problems such as powder adhesion occur during the production process. This study presents surface and structural characterization of tablets formulated with commonly used excipients (microcrystalline
Heikki O Koskela et al.
Chest, 124(6), 2171-2177 (2003-12-11)
To compare a new bronchial provocation test, the mannitol challenge, with cold air and histamine challenges to demonstrate airway hyperresponsiveness (AHR) in patients with difficult-to-diagnose asthma. A prospective study. Thirty-seven consecutive patients with recently diagnosed, steroid-naive, mild, or atypical asthma
Diana Bilton et al.
Thorax, 69(12), 1073-1079 (2014-09-24)
Bronchiectasis is characterised by excessive production of mucus and pulmonary exacerbations. Inhaled osmotic agents may enhance mucociliary clearance, but few long-term clinical trials have been conducted. To determine the impact of inhaled mannitol on exacerbation rates in patients with non-cystic
Heikki O Koskela et al.
Chest, 125(6), 1985-1992 (2004-06-11)
To define whether coughing during mannitol challenge is a nonspecific side effect of this challenge or is associated with asthma. A prospective study. University hospital. Thirty-seven steroid-naive, asthmatic subjects and 10 healthy subjects. The participants completed a symptom questionnaire, recorded
Heikki O Koskela et al.
Chest, 124(4), 1341-1349 (2003-10-14)
To compare the sensitivity and validity of mannitol, histamine, and cold air challenges to demonstrate the effect of inhaled corticosteroids (ICS) in asthma. A prospective study. Seventeen patients with recently diagnosed, steroid-naive asthma who fulfilled the diagnostic criteria of Finnish
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