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157481

4-Nitrochalcone

Name: 4-Nitrochalcone
Brand: ALDRICH

99%

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About This Item

Linear Formula:

O₂NC₆H₄CH=CHCOC₆H₅

CAS Number:

1222-98-6

Molecular Weight:

253.25

NACRES:

NA.22

PubChem Substance ID:

24849682

UNSPSC Code:

12352100

EC Number:

214-949-5

MDL number:

MFCD00007382

Assay:

99%

Form:

solid

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Properties

assay

99%

form

solid

mp

158-160 °C (lit.)

functional group

ketone, nitro, phenyl

SMILES string

[O-][N+](=O)c1ccc(\C=C\C(=O)c2ccccc2)cc1

InChI

1S/C15H11NO3/c17-15(13-4-2-1-3-5-13)11-8-12-6-9-14(10-7-12)16(18)19/h1-11H/b11-8+

InChI key

WDZGGAFMGIOIQS-DHZHZOJOSA-N

Description

General description

Mutagenic activity of 4-nitrochalcone on two strains of Salmonella typhimurium (TA98 and TA100) with and without rat liver microsomal and cytosolic enzymes has been tested.

Application

4-Nitrochalcone was used in the synthesis of 2,3-dibromo-4-nitrochalcone.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Synthesis and Photochromic Properties of New Heterocyclic Derivatives of 1, 3-Diazabicyclo [3.1. 0] Hex-3-Ene.

Mahmoodi NO, et al.

J. Chin. Chem. Soc., 54(3), 635-641 (2007)

Structure-mutagenicity relationships of chalcones and their oxides in the Salmonella assay.

K A Rashid et al.

Mutation research, 169(3), 71-79 (1986-03-01)

31 p-monosubstituted chalcones (E-1, 3-diphenylpropene-1-one) and the corresponding oxides (E-1-benzoyl-2-phenyloxirane) were tested for mutagenic activity on two strains of Salmonella typhimurium (TA98 and TA100) with and without rat liver microsomal and cytosolic enzymes. Highest mutagenicity (3.0 revertants/nmole in either strain)

4-nitrochalcone exerts leishmanicidal effect on L. amazonensis promastigotes and intracellular amastigotes, and the 4-nitrochalcone encapsulation in beeswax copaiba oil nanoparticles reduces macrophages cytotoxicity.

João Paulo Assolini et al.

European journal of pharmacology, 884, 173392-173392 (2020-08-01)

The Leishmaniasis treatment currently available involves some difficulties, such as high toxicity, variable efficacy, high cost, therefore, it is crucial to search for new therapeutic alternatives. Over the past few years, research on new drugs has focused on the use

Global Trade Item Number

SKU	GTIN
157481-25G	04061838743381