161136
3-Hydroxytyramine hydrobromide
99%
Synonym(s):
3,4-Dihydroxyphenethylamine hydrobromide, Dopamine hydrobromide
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About This Item
Linear Formula:
(HO)2C6H3CH2CH2NH2·HBr
CAS Number:
Molecular Weight:
234.09
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Assay
99%
form
solid
mp
218-220 °C (lit.)
SMILES string
Br.NCCc1ccc(O)c(O)c1
InChI
1S/C8H11NO2.BrH/c9-4-3-6-1-2-7(10)8(11)5-6;/h1-2,5,10-11H,3-4,9H2;1H
InChI key
SGRSNYSOAPBTJP-UHFFFAOYSA-N
Application
3-Hydroxytyramine hydrobromide was used in the preparation of dopamine standards to measure the dopamine release and uptake in striatal brain slices from R6/1 HD model mice by fast-scan cyclic voltammetry. It was employed as internal standard in the determination of catecholamines in biological tissues by liquid chromatography.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Determination of catecholamines in biological tissues by liquid chromatography with coulometric detection.
G de Saint Blanquat et al.
Journal of chromatography, 415(2), 388-392 (1987-04-10)
Andrea N Ortiz et al.
Neuroscience letters, 492(1), 11-14 (2011-01-25)
Huntington's disease (HD) is a progressive, neurodegenerative movement disorder. Here, we used fast-scan cyclic voltammetry to measure dopamine release and uptake in striatal brain slices from R6/1 HD model mice. Peak dopamine release ([DA](max)) was significantly diminished in R6/1 mice
Azam Sargazi et al.
Colloids and surfaces. B, Biointerfaces, 171, 150-158 (2018-07-20)
Hyaluronic acid (HA) is increasingly investigated for biomedical applications such as regenerative medicine, aesthetic medicine, and drug delivery. Accordingly, conjugation of HA to PEGylated MNPs could increase the active targeting ability of nano-drug carriers toward CD44 receptors and be useful
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