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Merck
CN

161462

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC) 98%

≥98%

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About This Item

Empirical Formula (Hill Notation):
C8H17N3 · HCl
CAS Number:
25952-53-8
Molecular Weight:
191.70
UNSPSC Code:
12352100
PubChem Substance ID:
329751124
EC Number:
247-361-2
MDL number:
MFCD00012503

Key Documents

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InChI key

FPQQSJJWHUJYPU-UHFFFAOYSA-N

InChI

1S/C8H17N3.ClH/c1-4-9-8-10-6-5-7-11(2)3;/h4-7H2,1-3H3;1H

SMILES string

Cl.CCN=C=NCCCN(C)C

assay

≥98%

mp

111-113 °C (lit.)

Application

Coupling reagent used to form amide bonds in oligonucleotides and tetraazamacrocycles.
Water soluble carbodiimide for the preparation of chloroanthraquinone hydrazides, which unexpectedly cyclize to anthrapyrazoles (en route to developing histochemical probes).

Other Notes

This product has been replaced by E7750-Sigma-Aldrich | N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride commercial grade, powder

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral

target_organs

Stomach,large intestine,lymph node

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
07710EW
05820MW
02804BP
01226KV
22131JI

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Tetrahedron Letters, 45, 4977-4980 (2004)
Tetrahedron Letters, 34, 7685-7685 (1993)
T J McMurry et al.
Bioconjugate chemistry, 3(2), 108-117 (1992-03-01)
A convenient synthesis of 4-nitrobenzyl-substituted macrocyclic tetraamines and their conversion to bifunctional poly(amino carboxylate) chelating agents is described. Cyclization of (4-nitrobenzyl)-ethylenediamine with appropriate BOC-protected amino disuccinimido esters in dioxane at 90 degrees C resulted in the formation of 12- and
Tetrahedron Letters, 34, 6189-6189 (1993)
Sabine Hauptstein et al.
Journal of pharmaceutical sciences, 103(2), 594-601 (2014-01-03)
The objective of this study was to generate a water-soluble thiolated chitosan to enable the permeation-enhancing effect of chitosan at pH of at least 5.5 without losing the advantages of improved mucoadhesive properties. Therefore, the thiol-bearing polyoxyethylene ligand {O-(3-carboxylpropyl)-O'-[2-[3-mercaptopropionylamino)ethyl]-polyethyleneglycol} was
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