161543
5-(4-Hydroxyphenyl)-5-phenylhydantoin
98%
Synonym(s):
4-Hydroxydiphenylhydantoin, p-Hydroxyphenytoin, NSC 156081
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About This Item
Empirical Formula (Hill Notation):
C15H12N2O3
CAS Number:
Molecular Weight:
268.27
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
220-492-2
MDL number:
Assay:
98%
Form:
solid
assay
98%
form
solid
mp
>300 °C (lit.)
solubility
soluble 50 mg/mL, clear, colorless to faintly yellow (DMF:MeOH(2:1))
functional group
phenyl
SMILES string
Oc1ccc(cc1)C2(NC(=O)NC2=O)c3ccccc3
InChI
1S/C15H12N2O3/c18-12-8-6-11(7-9-12)15(10-4-2-1-3-5-10)13(19)16-14(20)17-15/h1-9,18H,(H2,16,17,19,20)
InChI key
XEEDURHPFVXALT-UHFFFAOYSA-N
General description
5-(4-Hydroxyphenyl)-5-phenylhydantoin is the major metabolite of phenytoin.
Application
5-(4-Hydroxyphenyl)-5-phenylhydantoin was used in enantiomeric separation of chiral pharmaceuticals using a teicoplanin chiral stationary phase by aqueous and non-aqueous packed capillary electrochromatography. It was used as internal standard in determination of phenylbutazone and its metabolite oxyphenbutazone in human plasma by GLC.
Reactant for activation of hydroxylated metabolites of carbamazepine and phenytoin
Used in studies investigating
Transport across the human placenta barrier
Effects on cellular glucose transport
Used in studies investigating
Transport across the human placenta barrier
Effects on cellular glucose transport
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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