161896
3,4-Dibenzyloxyphenethylamine hydrochloride
98%
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About This Item
Linear Formula:
(C6H5CH2O)2C6H3CH2CH2NH2 · HCl
CAS Number:
Molecular Weight:
369.88
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
216-924-4
MDL number:
Assay:
98%
InChI key
KXIZXPRLNNDQKS-UHFFFAOYSA-N
InChI
1S/C22H23NO2.ClH/c23-14-13-18-11-12-21(24-16-19-7-3-1-4-8-19)22(15-18)25-17-20-9-5-2-6-10-20;/h1-12,15H,13-14,16-17,23H2;1H
SMILES string
Cl.NCCc1ccc(OCc2ccccc2)c(OCc3ccccc3)c1
assay
98%
mp
131-133 °C (lit.)
functional group
amine, phenyl
Application
3,4-Dibenzyloxyphenethylamine hydrochloride was used in the synthesis of tetrahydroisoquinoline derivatives containing 4(hexylureido)benzenesulfonamide, human β3 adrenergic receptor agonist. It was used as reagent in synthesis of the prodrugs of dopamine.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Lauri Peura et al.
Pharmaceutical research, 30(10), 2523-2537 (2013-10-19)
Drug delivery to the brain is impeded by the blood-brain barrier (BBB). Here, we attempted to enhance the brain uptake of cationic dopamine by utilizing the large amino acid transporter 1 (LAT1) at the BBB by prodrug approach. Three amino
E R Parmee et al.
Bioorganic & medicinal chemistry letters, 10(20), 2283-2286 (2000-10-31)
Tetrahydroisoquinoline derivatives containing a 4-(hexylureido)benzenesulfonamide were examined as human beta3 adrenergic receptor (AR) agonists. Notably, 4,4-biphenyl derivative 9 was a 6 nM full agonist of the beta3 AR. Naphthyloxy compound 18 (beta3 EC50 = 78 nM) did not activate the
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