162434
4-Chloro-2-phenylquinazoline
97%
Synonym(s):
AM-ex-OL, NSC 400965
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About This Item
Empirical Formula (Hill Notation):
C14H9ClN2
CAS Number:
Molecular Weight:
240.69
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
229-346-2
MDL number:
Assay:
97%
Form:
liquid
InChI key
OBHKONRNYCDRKM-UHFFFAOYSA-N
InChI
1S/C14H9ClN2/c15-13-11-8-4-5-9-12(11)16-14(17-13)10-6-2-1-3-7-10/h1-9H
SMILES string
Clc1nc(nc2ccccc12)-c3ccccc3
assay
97%
form
liquid
mp
124-126 °C (lit.)
Application
4-Chloro-2-phenylquinazoline was used in synthesis of axially chiral quinazoline-containing phosphinamine ligand, N,N,2-triphenylquinazolin-4-amine, sulfanyl and sulfinylbenzodiazines. It was used as reagent for the conversion of phenols to anilines.
Reactant involved in the synthesis of biologically active molecules including:
Reactant involved in Suzuki-Miyaura cross-coupling and catalyst-free / base-free water promoted nucleophilic aromatic substitution
- Nitrotriazole amines or nitroimidazole amines for use as antitrypanosomal activity and mammalian cytotoxicity
- Quinazoline-containing piperazinylpyrimidine derivatives with antitumor activity
- Quinazoline substituted cyclopentane as HCV NS3/4A protease inhibitors
- Quinazolines with antibacterial and antitumor activity
- Aurora inhibitor MK-0457
Reactant involved in Suzuki-Miyaura cross-coupling and catalyst-free / base-free water promoted nucleophilic aromatic substitution
Legal Information
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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The Journal of Organic Chemistry, 37, 1681-1681 (1972)
A highly efficient red electrophosphorescent iridium (iii) complex containing phenyl quinazoline ligand in polymer light-emitting diodes.
Mei Q, et al.
Journal of Materials Chemistry, 22(14), 6878-6884 (2012)
Syntheses of sulfoxide derivatives in the benzodiazine series. Diazines. Part 37.
Le Fur N, et al.
Tetrahedron, 60(36), 7983-7994 (2004)
The Journal of Organic Chemistry, 29, 1893-1893 (1964)
The preparation and resolution of 2-phenyl-Quinazolinap, a new atropisomeric phosphinamine ligand for asymmetric catalysis.
McCarthy M, et al.
Tetrahedron Asymmetry, 10(14), 2797-2807 (1999)
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