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Sigma-Aldrich

α-Hydroxyisobutyric acid

98%

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Synonym(s):
alpha-Hydroxyisobutyric acid, 2-Hydroxy-2-methylpropionic acid, 2-Methyllactic acid
Linear Formula:
(CH3)2C(OH)COOH
CAS Number:
Molecular Weight:
104.10
Beilstein:
1744739
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

98%

form

solid

bp

84 °C/1.5 mmHg (lit.)

mp

76-80 °C (lit.)

solubility

water: soluble 10%, clear to very slightly hazy, colorless

SMILES string

CC(C)(O)C(O)=O

InChI

1S/C4H8O3/c1-4(2,7)3(5)6/h7H,1-2H3,(H,5,6)

InChI key

BWLBGMIXKSTLSX-UHFFFAOYSA-N

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General description

α-Hydroxyisobutyric acid (2-hydroxyisobutyric acid) is the building block for polymer synthesis. It forms complexes with Eu(III) and has been studied by time resolved fluorescence spectroscopy.

Application

α-Hydroxyisobutyric acid was used as background electrolyte for separation and detection of the metal ions by on-line cyclic voltammetry.

Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Experimental factors in pulsed electrochemical detection in capillary electrophoresis.
Wen J, et al.
Journal of Chromatography A, 811(1), 181-192 (1998)
Thore Rohwerder et al.
Microbial cell factories, 9, 13-13 (2010-02-27)
Nowadays a growing demand for green chemicals and cleantech solutions is motivating the industry to strive for biobased building blocks. We have identified the tertiary carbon atom-containing 2-hydroxyisobutyric acid (2-HIBA) as an interesting building block for polymer synthesis. Starting from
Y Shigematsu et al.
Pediatric research, 16(9), 771-775 (1982-09-01)
Organic acids in plasma and urine of a patient with isovaleric acidemia were measured serially during a severe ketoacidotic attack. Urinary ketone bodies, lactic acid and 2-hydroxy-n-butyric acid changed in parallel with the plasma isovaleric acid concentration, which was correlated
M Bandell et al.
The Journal of biological chemistry, 275(50), 39130-39136 (2000-09-20)
The citrate transporter of Leuconostoc mesenteroides (CitP) catalyzes exchange of divalent anionic citrate from the medium for monovalent anionic lactate, which is an end product of citrate degradation. The exchange generates a membrane potential and thus metabolic energy for the
J D Pleil et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 12(4), 331-348 (2007-06-15)
Adverse health risks from environmental agents are generally related to average (long-term) exposures. Because a given individual's contact with a pollutant is highly variable and dependent on activity patterns, local sources and exposure pathways, simple 'snapshot' measurements of surrounding environmental

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