167398
tert-Butyl carbamate
98%
Synonym(s):
Boc-amide
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About This Item
Linear Formula:
NH2COOC(CH3)3
CAS Number:
Molecular Weight:
117.15
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
224-209-3
Beilstein/REAXYS Number:
1744500
MDL number:
Assay:
98%
Form:
solid
Quality Level
assay
98%
form
solid
mp
105-108 °C (lit.)
functional group
amine
SMILES string
CC(C)(C)OC(N)=O
InChI
1S/C5H11NO2/c1-5(2,3)8-4(6)7/h1-3H3,(H2,6,7)
InChI key
LFKDJXLFVYVEFG-UHFFFAOYSA-N
General description
Palladium-catalyzed cross-coupling reaction of tert-butyl carbamate with various aryl(Het) halides with Cs2CO3 as base in 1,4-dioxane (solvent) has been investigated.
Application
tert-Butyl carbamate was used in palladium-catalyzed synthesis of N-Boc-protected anilines. It was used in the synthesis of tetrasubstituted pyrroles, functionalized with ester or ketone groups at C-3 position.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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One-Pot Three-Component Synthesis of Tetrasubstituted NH Pyrroles from Secondary Propargylic Alcohols, 1, 3-Dicarbonyl Compounds and tert-Butyl Carbamate.
Cadierno V, et al.
Journal of Heterocyclic Chemistry, 47(1), 233-236 (2010)
Swapna Bhagwanth et al.
The Journal of organic chemistry, 74(12), 4634-4637 (2009-06-13)
The scope of Pd-catalyzed synthesis of N-Boc-protected anilines from aryl bromides and commercially available tert-butyl carbamate is described. For the first time, this process can be conducted at room temperature (17-22 degrees C) using a combination of Pd(2)dba(3).CHCl(3) and a
Maximilian Tromayer et al.
Polymer chemistry, 8(2), 451-460 (2017-03-07)
The possibility of the direct encapsulation of living cells
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 167398-100G | 04061832763187 |
| 167398-25G | 04061838749567 |
| 167398-5G | 04061838749574 |
| 167398-1G | 04061826216316 |