174823
4-Quinolinecarboxylic acid
97%
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About This Item
Empirical Formula (Hill Notation):
C10H7NO2
CAS Number:
Molecular Weight:
173.17
Beilstein:
5224
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Assay
97%
mp
254-255 °C (lit.)
functional group
carboxylic acid
SMILES string
OC(=O)c1ccnc2ccccc12
InChI
1S/C10H7NO2/c12-10(13)8-5-6-11-9-4-2-1-3-7(8)9/h1-6H,(H,12,13)
InChI key
VQMSRUREDGBWKT-UHFFFAOYSA-N
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Application
4-Quinolinecarboxylic acid was used in the coupling reaction with diamine linker. A 4-quinolinecarboxylic acid analogue, brequinar sodium was used to inhibit dihydroorotate dehydrogenase and the de novo biosynthesis of pyrimidine.
Biochem/physiol Actions
4-Quinolinecarboxylic acid showed anti-tumor activity against L1210 leukemia and B16 melanoma.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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A J Dobson et al.
Acta crystallographica. Section C, Crystal structure communications, 54 ( Pt 12), 1883-1885 (1999-01-28)
The title acid, C10H7NO2, crystallized in the centrosymmetric space group P2(1)/c with one molecule in the asymmetric unit. There is a single hydrogen bond. O-H...N, with a donor-acceptor distance of 2.596 (1) A. The carboxylic H atom is ordered. The
A J Dobson et al.
Acta crystallographica. Section C, Crystal structure communications, 55 ( Pt 6), 935-937 (1999-07-17)
The title acid, C10H7NO2.2H2O, crystallized in the non-centrosymmetric space group Cc with one zwitterionic organic molecule and two water molecules in the asymmetric unit. One N-H...O and four O-H...O hydrogen bonds are present in this structure, with donor-acceptor distances ranging
M-J Chen et al.
European review for medical and pharmacological sciences, 23(10), 4360-4367 (2019-06-08)
The aim of this work was to explore whether lncRNA-MEG3 could serve as a serum biomarker for diagnosing chronic hepatitis B (CHB) and improve the early diagnostic and treatment efficacies. Serum level of lncRNA-MEG3 in CHB patients and healthy controls
[3-hydroxy-2-phenylcinchonine acid therapy of rheumatic fever].
M IVERSEN
Ugeskrift for laeger, 113(26), 851-855 (1951-06-28)
W Knecht et al.
Biochemical pharmacology, 56(9), 1259-1264 (1998-11-05)
The isoxazol leflunomide (N-(4-trifluoromethylphenyl)-5-methylisoxazol-4-carboxamide) and its active metabolite A77-1726 (N-(4-trifluoromethyl)-phenyl-2-cyano-3-hydroxy-crotonic acidamide) are promising disease-modifying antirheumatic drugs now in clinical trials. The malononitrilamides MNA279 (2-cyano-3-cyclopropyl-3-oxo-(4-cyanophenyl)propionamide) MNA715(N-(4-trifluoromethyl)-phenyl-2-cyano-3-hydroxy-hept-2-en-6- in-carboxylic acidamide) and HR325 (1(3-methyl-4-trifluoro methylphenyl-carbamoyl)-2-cyclopropyl-2oxo-propionitrile) were shown to block rejection after allograft and xenograft
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