176478
3-(4-Fluorobenzoyl)propionic acid
97%
Synonym(s):
Haloperidol metabolite III, R 11302
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About This Item
Linear Formula:
FC6H4COCH2CH2CO2H
CAS Number:
Molecular Weight:
196.18
EC Number:
MDL number:
UNSPSC Code:
12352100
eCl@ss:
39040324
PubChem Substance ID:
NACRES:
NA.22
Assay
97%
form
solid
mp
100-102 °C (lit.)
SMILES string
OC(=O)CCC(=O)c1ccc(F)cc1
InChI
1S/C10H9FO3/c11-8-3-1-7(2-4-8)9(12)5-6-10(13)14/h1-4H,5-6H2,(H,13,14)
InChI key
WUYWHIAAQYQKPP-UHFFFAOYSA-N
General description
3-(4-Fluorobenzoyl)propionic acid is a metabolite of haloperidol, a dopamine D2 receptor blocker.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Sarita Forsback et al.
Synapse (New York, N.Y.), 51(2), 119-127 (2003-11-18)
In order to characterize the sensitivity of an analog of levodopa and a dopamine transporter ligand to detect defects in nigrostriatal function, the uptake of [(18)F]FDOPA and [(18)F]CFT was studied ex vivo in a rat model of Parkinson's disease. The
G A Digenis et al.
Journal of pharmaceutical sciences, 70(9), 985-989 (1981-09-01)
Tissue distribution studies of [18F]haloperidol and [82Br]bromperidol, two potent neuroleptic drugs, were performed in rats by serial sacrifice. The usefulness of external scintigraphy in obtaining tissue distribution data in large animals is demonstrated by the tissue distribution of [18F]haloperidol in
M Watanabe et al.
Xenobiotica; the fate of foreign compounds in biological systems, 29(8), 839-846 (1999-12-20)
1. The aim was to identify whether CYP3A metabolizes bromperidol (BP), an antipsychotic drug, to form 4-fluorobenzoyl-propionic acid (FBPA) in hepatic microsomes from 8-week-old male Sprague-Dawley rats and to investigate whether an inhibitor or an inducer of CYP3A affects BP
Hyeon Soo Kim et al.
Journal of neurochemistry, 99(2), 458-469 (2006-10-13)
Haloperidol, a dopamine D2 receptor blocker, is a classical neuroleptic drug that elicits extrapyramidal symptoms. Its metabolites include 3-(4-fluorobenzoyl) propionic acid (FBPA) and 4-(4-chlorophenyl)-4-piperidinol (CPHP). Until now, the biological significance of these metabolites has remained largely unknown. Here, we report
M Watanabe et al.
Fundamental & clinical pharmacology, 13(3), 337-342 (1999-07-07)
Haloperidol (HP), an antipsychotic drug, is N-dealkylated by cytochrome P450 (CYP) to 4-fluorobenzoylpropionic acid (FBPA). The purpose of this study was to identify whether CYP3A metabolizes HP to FBPA in hepatic microsomes of rats and to investigate whether an inhibitor
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