178330
4-Amino-1-butanol
98%
Synonym(s):
4-Hydroxybutylamine
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About This Item
Linear Formula:
H2N(CH2)4OH
CAS Number:
Molecular Weight:
89.14
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
236-364-4
Beilstein/REAXYS Number:
1731411
MDL number:
Assay:
98%
Form:
liquid
InChI key
BLFRQYKZFKYQLO-UHFFFAOYSA-N
InChI
1S/C4H11NO/c5-3-1-2-4-6/h6H,1-5H2
SMILES string
NCCCCO
assay
98%
form
liquid
refractive index
n20/D ~1.462 (lit.)
bp
206 °C (lit.)
Quality Level
density
0.967 g/mL at 25 °C (lit.)
functional group
amine, hydroxyl
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Application
4-Amino-1-butanol was used in the synthesis of cyclic amines.
4-Amino-1-butanol was used:
- As a linker in the synthesis of highly branched poly(β-amino esters)(HPAEs) for gene delivery.
- As a side chain to modulate antimicrobial and hemolytic activities of copolymers.
- In the total synthesis of (+)-fawcettimine,(+)-fawcettidine, and (−)-lycojapodine A.
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
Storage Class
8A - Combustible corrosive hazardous materials
wgk
WGK 2
flash_point_f
219.2 °F - closed cup
flash_point_c
104 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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Christopher L Grigsby et al.
Scientific reports, 3, 3155-3155 (2013-11-07)
As the designs of polymer systems used to deliver nucleic acids continue to evolve, it is becoming increasingly apparent that the basic bulk manufacturing techniques of the past will be insufficient to produce polymer-nucleic acid nanocomplexes that possess the uniformity
Highly branched poly (β-amino esters): Synthesis and application in gene delivery.
Cutlar L, et al.
Biomacromolecules, 16(9), 2609-2617 (2015)
Cationic spacer arm design strategy for control of antimicrobial activity and conformation of amphiphilic methacrylate random copolymers.
Palermo E F, et al.
Biomacromolecules, 13(5), 1632-1641 (2012)
Total Syntheses of Lycopodium Alkaloids (+)?Fawcettimine,(+)?Fawcettidine, and (−)?8?Deoxyserratinine.
Li H, et al.
Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 124(2), 506-510 (2012)
Collective synthesis of lycopodium alkaloids and tautomer locking strategy for the total synthesis of (−)-lycojapodine A.
Li H, et al.
The Journal of Organic Chemistry, 78(3), 800-821 (2012)
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