178950
Methanesulfonyl fluoride
98%
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About This Item
Linear Formula:
CH3SO2F
CAS Number:
Molecular Weight:
98.10
UNSPSC Code:
12352100
PubChem Substance ID:
EC Number:
209-192-2
MDL number:
InChI key
KNWQLFOXPQZGPX-UHFFFAOYSA-N
InChI
1S/CH3FO2S/c1-5(2,3)4/h1H3
SMILES string
CS(F)(=O)=O
assay
98%
reaction suitability
reaction type: click chemistry
bp
123-124 °C (lit.)
density
1.427 g/mL at 25 °C (lit.)
General description
Methanesulfonyl fluoride is an anticholinesterase (antiChEs), used to treat Alzheimer′s disease. It is a thrombin inhibitor.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Skin Corr. 1B
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Regulatory Information
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A W Snow et al.
Chemical research in toxicology, 1(6), 379-384 (1988-11-01)
The chemical reactivity and physical properties of methanesulfonyl fluoride (MSF) were quantitatively measured for direct comparison with those of isopropyl methylphosphonofluoridate (GB, sarin) and diisopropyl phosphorofluoridate (DFP). The chemistry involved reaction rate constant measurements of MSF hydrolysis and for reactions
D H Malin et al.
Neurobiology of aging, 14(4), 393-395 (1993-07-01)
Aged (24-month-old) rats were treated chronically with methanesulfonyl fluoride (MSF), an acetylcholinesterase (AChE) inhibitor with selectivity for central nervous system AChE, or with injection vehicle alone. Twelve 0.22 mg/kg IP injections were given over 4 weeks. MSF rats showed significantly
Weixuan Chen et al.
Biotechnology letters, 36(2), 337-340 (2013-10-09)
Fibrinogen is essential in the intrinsic and extrinsic blood coagulation process. Inhibition of fibrinogen aggregation could lead to anticoagulation effects. The availability of methods for easy quantitative evaluation of the coagulation process is critical to studying coagulation and its inhibition.
J F Fiekers
The Journal of pharmacology and experimental therapeutics, 234(3), 539-549 (1985-09-01)
The actions of two reversible anticholinesterase agents, edrophonium and physostigmine, were compared with the irreversible agent methanesulfonyl fluoride (MSF) on miniature end-plate currents (MEPCs) and ACh-induced end-plate current fluctuations recorded from twitch fibers of costocutaneous muscles of garter snakes (Thamnophis
Nicholas P D Liau et al.
Nature communications, 9(1), 1558-1558 (2018-04-21)
The SOCS family of proteins are negative-feedback inhibitors of signalling induced by cytokines that act via the JAK/STAT pathway. SOCS proteins can act as ubiquitin ligases by recruiting Cullin5 to ubiquitinate signalling components; however, SOCS1, the most potent member of
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