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179000

Benzo-1,4-dioxane

Name: Benzo-1,4-dioxane
Brand: ALDRICH

97%

Synonym(s):

1,2-Ethylenedioxybenzene, 1,4-Benzodioxan, 2,3-Dihydro-1,4-benzodioxin

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About This Item

Empirical Formula (Hill Notation):

C₈H₈O₂

CAS Number:

493-09-4

Molecular Weight:

136.15

UNSPSC Code:

12352100

NACRES:

NA.21

PubChem Substance ID:

24850788

EC Number:

207-775-6

Beilstein/REAXYS Number:

120846

MDL number:

MFCD00006821

Assay:

97%

Form:

liquid

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Properties

Quality Level

100

assay

97%

form

liquid

refractive index

n20/D 1.549 (lit.)

bp

103 °C/6 mmHg (lit.)

density

1.142 g/mL at 25 °C (lit.)

SMILES string

C1COc2ccccc2O1

InChI

1S/C8H8O2/c1-2-4-8-7(3-1)9-5-6-10-8/h1-4H,5-6H2

InChI key

BNBQRQQYDMDJAH-UHFFFAOYSA-N

Description

General description

The anti-inflammamtory properties and synthesis of carboxylic acid compounds containing benzo-1,4-dioxane (2,3-dihydro-1,4-benzodioxin) subunit was studied.

Application

Benzo-1,4-dioxane (2,3-dihydro-1,4-benzodioxin) was used in the synthesis of stereoisomers which were evaluated as α- and β- adrenergic antagonists.

hcodes

H412

pcodes

P273 - P501

Hazard Classifications

Aquatic Chronic 3

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

156.2 °F - closed cup

flash_point_c

69 °C - closed cup

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

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Synthesis and alpha,beta-adrenergic blocking potency of 2,3-dihydro-1,4-benzodioxin derivatives. (II).

M Khouili et al.

Farmaco (Societa chimica italiana : 1989), 51(3), 185-188 (1996-03-01)

The four stereoisomers of compound 1 were synthesized from 2,3-dihydro-1, 4-benzodioxin and evaluated as alpha- and beta-adrenergic antagonists. Enantiomer 1-b [2R, 2'S] (Figure 1) is the best beta 1-blocking agent. Furthermore all compounds showed a alpha-blocking activity.

Synthesis and antiinflammatory activity of 2,3-dihydro-1,4-benzodioxin methyl carboxylic acids.

M T Vázquez et al.

Farmaco (Societa chimica italiana : 1989), 51(3), 215-217 (1996-03-01)

Synthesis and antiinflammatory properties of new carboxylic acids containing the 2,3-dihydro-1,4-benzodioxin subunit are described. The 2-(2,3-dihydro-1, 4-benzodioxin-6-yl)acetic acid was of comparable potency to Ibuprofen, in carrageenan induced rat paw edema assay.

Global Trade Item Number

SKU	GTIN
179000-50G	04061838118363