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185892

Ethyl chloroformate

97%

Synonym(s):

Chloroformic acid ethyl ester

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About This Item

Linear Formula:
ClCOOC2H5
CAS Number:
541-41-3
Molecular Weight:
108.52
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24851187
EC Number:
208-778-5
Beilstein/REAXYS Number:
385653
MDL number:
MFCD00000644
Assay:
97%
Form:
liquid
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vapor density

3.74 (vs air)

Quality Level

200

vapor pressure

3.42 psi ( 20 °C)

assay

97%

form

liquid

autoignition temp.

842 °F

refractive index

n20/D 1.395 (lit.)

bp

93 °C (lit.)

mp

−81 °C (lit.)

solubility

alcohol: miscible, benzene: miscible, chloroform: miscible, diethyl ether: miscible, water: insoluble

density

1.135 g/mL at 25 °C (lit.)

functional group

chloro

SMILES string

CCOC(Cl)=O

InChI

1S/C3H5ClO2/c1-2-6-3(4)5/h2H2,1H3

InChI key

RIFGWPKJUGCATF-UHFFFAOYSA-N

Application

  • Ethyl chloroformate was used in the synthesis of nitrile oxides.
  • It was used as derivatization reagent to investigate stereochemical conversion of chiral non-steroidal anti-inflammatory drugs during derivatization reaction.
  • It was used to develop flexible template strategy for the generation of nanometer-scale templates via dip-pen nanolithography.
  • It was used as derivatization reagent in an enantiomeric analysis of amino acids by two-dimensional gas chromatography.
  • It was also used with ammonia and cyanuric chloride to convert carboxylic acids to nitriles.

Packaging

Derivatization reagent employed in an enantiomeric analysis of amino acids by two-dimensional gas chromatography. Also used with ammonia and cyanuric chloride to convert carboxylic acids to nitriles.

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Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Met. Corr. 1 - Skin Corr. 1B

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

60.8 °F

flash_point_c

16 °C

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM9940
BCCL3605
MKCW9129
MKCW8445
0000379777

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Sezin Erarpat et al.
Journal of separation science, 43(6), 1100-1106 (2019-12-21)
A green and fast analytical method for the determination of l-methionine in human plasma is presented in this study. Preconcentration of the analyte was carried out by switchable solvent liquid phase microextraction after ethyl chloroformate derivatization reaction. Instrumental detection of
M R Wright et al.
Journal of chromatography, 616(1), 59-65 (1993-06-23)
A potential problem with chiral derivatization is the possibility of stereochemical conversion during the derivatization reaction. This possibility has been examined using the non-steroidal anti-inflammatory drugs ibuprofen, ketoprofen, etodolac and flurbiprofen. To avoid possible interference from stereochemical impurities, male Sprague-Dawley
Tetrahedron Letters, 48, 1465-1465 (2007)
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Global Trade Item Number

SKUGTIN
185892-2KG04061833544945
185892-100G04061838757715
185892-5G04061838757739
185892-PZ04061823589611
185892-500G04061838757722