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188204

p-Toluenesulfonylmethyl isocyanide

98%

Synonym(s):

(p-Tolylsulfonyl)methyl isocyanide, TosMIC, Tosylmethyl isocyanide

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About This Item

Linear Formula:
CH3C6H4SO2CH2NC
CAS Number:
36635-61-7
Molecular Weight:
195.24
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24851306
EC Number:
253-140-1
Beilstein/REAXYS Number:
3592382
MDL number:
MFCD00000005
Assay:
98%
Form:
solid
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Quality Segment

assay

98%

form

solid

mp

109-113 °C (lit.)

solubility

water: slightly soluble

functional group

amine, isonitrile, sulfone

storage temp.

2-8°C

SMILES string

Cc1ccc(cc1)S(=O)(=O)C[N+]#[C-]

InChI

1S/C9H9NO2S/c1-8-3-5-9(6-4-8)13(11,12)7-10-2/h3-6H,7H2,1H3

InChI key

CFOAUYCPAUGDFF-UHFFFAOYSA-N

General description

p-Toluenesulfonylmethyl isocyanide undergoes base-promoted 1,3-dipolar cycloaddition reaction with immobilized imines under microwave irradiation to yield 1,5-disubstituted imidazoles. It is a versatile synthon in organic chemistry, extensively used for the synthesis of heterocyclic compounds.

Application

p-Toluenesulfonylmethyl isocyanide was used:
  • in the synthesis of triplet drugs with the 1,3,5-trioxazatriquinane skeleton
  • as reagent in the preparation of biologically active pyrroles and imidazoles
  • as the isonitrile component in a diastereoselective Passerini reaction employing sugar-derived aldehydes

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Codes

H300 + H310 + H330

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

supp_hazards

EUH032

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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