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188425

3-Methylindene-2-carboxylic acid

Name: 3-Methylindene-2-carboxylic acid
Brand: ALDRICH

98%

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₀O₂

CAS Number:

34225-81-5

Molecular Weight:

174.20

NACRES:

NA.22

PubChem Substance ID:

24851160

UNSPSC Code:

12352100

EC Number:

251-888-3

MDL number:

MFCD00044428

Assay:

98%

Form:

powder

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Properties

assay

98%

form

powder

mp

201-203 °C (lit.)

SMILES string

CC1=C(Cc2ccccc12)C(O)=O

InChI

1S/C11H10O2/c1-7-9-5-3-2-4-8(9)6-10(7)11(12)13/h2-5H,6H2,1H3,(H,12,13)

InChI key

RONBYWGSEXDEKC-UHFFFAOYSA-N

Description

General description

3-Methylindene-2-carboxylic acid undergoes asymmetric hydrogenation over Pd/Al₂O₃ in the presence of cinchonidine as a chiral modifier.

Application

3-Methylindene-2-carboxylic acid was used in the synthesis of:

LKS01-B650, an imaging probe that selectively binds the catalytically active LMP7 subunit of immunoproteasome in living cells
1-methylindane-2-carboxylic acid via reduction with sodium amalgam

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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cis-and trans-2-Substituted 1-methylindanes.

Shadbolt, RS.

J. Chem. Soc. Sect. C, 7, 920-922 (1970)

Activity-based near-infrared fluorescent probe for LMP7: a chemical proteomics tool for the immunoproteasome in living cells.

Lalit Kumar Sharma et al.

Chembiochem : a European journal of chemical biology, 13(13), 1899-1903 (2012-07-19)

Probing the unknown: The immunoproteasome, an alternative form of the constitutive proteasome, has been implicated in a number of pathological states such as cancer and autoimmune diseases. In an effort to understand the role of the immunoproteasome in cells, the

Asymmetric hydrogenation of indene carboxylic acids: stereochemistry of hydrogen addition.

Borszeky K, et al.

Tetrahedron Asymmetry, 10(24), 4781-4789 (1999)

Global Trade Item Number

SKU	GTIN
188425-2.5G	04061831810011