191736
Pargyline hydrochloride
99%
Synonym(s):
N-Methyl-N-(2-propynyl)benzylamine hydrochloride, N-Methyl-N-propargylbenzylamine hydrochloride
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About This Item
Linear Formula:
C6H5CH2N(CH3)CH2C≡CH·HCl
CAS Number:
Molecular Weight:
195.69
Beilstein:
3699487
EC Number:
MDL number:
UNSPSC Code:
12352103
PubChem Substance ID:
Assay
99%
mp
160-163 °C (lit.)
SMILES string
Cl[H].CN(CC#C)Cc1ccccc1
InChI
1S/C11H13N.ClH/c1-3-9-12(2)10-11-7-5-4-6-8-11;/h1,4-8H,9-10H2,2H3;1H
InChI key
BCXCABRDBBWWGY-UHFFFAOYSA-N
Gene Information
human ... MAOA(4128), MAOB(4129)
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Biochem/physiol Actions
Selective MAO-B inhibitor.
Regulatory Information
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Masahiro Yoshida et al.
The Journal of organic chemistry, 78(4), 1687-1692 (2013-02-01)
The reaction of propargylic carbonates with 4-hydroxy-2-pyrones in the presence of a palladium catalyst is described. By the choice of the reaction temperature, two types of the substituted furo[3,2-c]pyran-4-one derivatives were regioselectively synthesized, respectively.
Shauna N Vasilatos et al.
Carcinogenesis, 34(6), 1196-1207 (2013-01-29)
Our previous studies demonstrated that lysine-specific demethylase 1 (LSD1) and histone deacetylases (HDACs) closely interact in controlling growth of breast cancer cells. However, the underlying mechanisms are largely unknown. In this study, we showed that knockdown of LSD1 expression (LSD1-KD)
Zheng Jiang et al.
Organic letters, 14(24), 6266-6269 (2012-12-01)
An efficient and straightforward strategy for the synthesis of tetrasubstituted imidazoles from propargyl amines, sulfonyl azides, and terminal alkynes is described. N-sulfonyl ketenimine and aminoallene are believed to be the key intermediates for this two-step one-pot transformation.
Avanashiappan Nandakumar et al.
Organic letters, 15(2), 382-385 (2013-01-12)
Tetrasubstituted olefin based new xanthene derivatives have been synthesized via palladium-catalyzed carbopalladation/C-H activation of 2-bromobenzyl-N-propargylamine derivatives. The synthesized compounds display a pronounced solid state fluorescence due to their restricted internal rotation of a C-Ar bond in the solid or aggregation
Highly stereoselective synthesis of tertiary propargylic centers and their isomerization to enantiomerically enriched allenes.
José Luis García Ruano et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 18(32), 9775-9779 (2012-08-01)
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