192333
Ethyl nitroacetate
97%
Synonym(s):
2-Nitroacetic acid ethyl ester, Ethyl 2-nitroacetate, Nitroacetic acid ethyl ester
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About This Item
Linear Formula:
NO2CH2CO2C2H5
CAS Number:
Molecular Weight:
133.10
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
210-944-7
Beilstein/REAXYS Number:
1210027
MDL number:
Assay:
97%
InChI key
FTKASJMIPSSXBP-UHFFFAOYSA-N
InChI
1S/C4H7NO4/c1-2-9-4(6)3-5(7)8/h2-3H2,1H3
SMILES string
CCOC(=O)C[N+]([O-])=O
assay
97%
Quality Level
bp
105-107 °C/25 mmHg (lit.)
density
1.199 g/mL at 25 °C (lit.)
functional group
amine, ester, nitro
Related Categories
Application
Ethyl nitroacetate has been used in:
- synthesis of γ-oxoacids via Michael addition reaction with α,β-unsaturated ketones
- fuctionalization of C4-position on pyrimidine and C6-position on 2′-deoxyguanosine to produce novel nucleosides
- facile synthesis of α,α-diisobutylglycine
- synthesis of DL-4,4-difluoroglutamic acid
Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
197.6 °F - closed cup
flash_point_c
92 °C - closed cup
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
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Elena Trogu et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 18(7), 2081-2093 (2012-01-12)
Base-catalysed condensation reactions of nitroacetic esters with dipolarophiles to give isoxazole derivatives proceed faster, and often with higher yields, in the presence of water than in organic solvents such as chloroform. Kinetic profiles show that induction times are greatly reduced
Maialen Aginagalde et al.
The Journal of organic chemistry, 75(21), 7435-7438 (2010-10-05)
Michael addition of ethyl nitroacetate on α,β-unsaturated ketones followed by Nef oxidation under hydrolytic conditions yields γ-oxoacids instead of the corresponding α,δ-dioxoesters. A concerted decarboxylation step is proposed on the basis of computational results. Finally, conversion of the γ-ketoacids thus
T Tsukamoto et al.
Journal of medicinal chemistry, 39(1), 66-72 (1996-01-05)
DL-4,4-Difluoroglutamic acid (DL-4,4-F2Glu) and its methotrexate analogue, DL-gamma,gamma-difluoromethotrexate (DL-gamma,gamma-F2MTX), were synthesized and evaluated as alternate substrates or inhibitors of folate-dependent enzymes. Synthesis of DL-4,4-F2Glu involved the nitroaldol reaction of ethyl nitroacetate with a difluorinated aldehyde ethyl hemiacetal as a key
Yanwen Fu et al.
The Journal of organic chemistry, 68(25), 9854-9857 (2003-12-06)
alpha,alpha-Diisobutylglycine has been synthesized using a Pd-mediated dialkylation of ethyl nitroacetate as a key first step. The free alphaalphaAA is N(alpha)-protected and has been applied to the assembly of conformationally constrained peptide analogues. Mixed anhydrides from BOP-Cl and Fmoc-alphaalphaAA-OH are
Victor Timoshchuk
Nucleosides, nucleotides & nucleic acids, 24(5-7), 1043-1046 (2005-10-27)
A study of C-nucleophilic substitution at the C4-position on pyrimidine and C6-position on 2'-deoxyguanosine to produce novel nucleosides is presented with the spectroscopic properties of their respective substitution products. C4-(1,2,4-triazol-1-yl) pyrimidine nucleosides 1 were treated with nitroalkanes, malononitrile, acetylacetone, ethyl
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