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Merck
CN

192538

5-Chloro-2-(trichloromethyl)benzimidazole

95%

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About This Item

Empirical Formula (Hill Notation):
C8H4Cl4N2
CAS Number:
3584-66-5
Molecular Weight:
269.94
NACRES:
NA.22
PubChem Substance ID:
24851551
UNSPSC Code:
12352100
EC Number:
222-713-8
MDL number:
MFCD00005595

Key Documents

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Product Name

5-Chloro-2-(trichloromethyl)benzimidazole, 95%

InChI key

SIZGSKQSWJIWFP-UHFFFAOYSA-N

InChI

1S/C8H4Cl4N2/c9-4-1-2-5-6(3-4)14-7(13-5)8(10,11)12/h1-3H,(H,13,14)

SMILES string

Clc1ccc2[nH]c(nc2c1)C(Cl)(Cl)Cl

assay

95%

mp

223-224 °C (dec.) (lit.)

General description

The effect of 5-chloro-2-trichloromethyl benzimidazole on binding affinity of human growth hormone (hGH) (Thr175 → Gly–hGH) to the extracellular domain of the hGH receptor (Trp104 → Gly–hGHbp) has been investigated.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
15614TE
10420PB
11431AO
05130EB

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Z Guo et al.
Science (New York, N.Y.), 288(5473), 2042-2045 (2000-06-17)
Mutations introduced into human growth hormone (hGH) (Thr175 --> Gly-hGH) and the extracellular domain of the hGH receptor (Trp104 --> Gly-hGHbp) created a cavity at the protein-protein interface that resulted in binding affinity being reduced by a factor of 10(6).

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