192538
5-Chloro-2-(trichloromethyl)benzimidazole
95%
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About This Item
Empirical Formula (Hill Notation):
C8H4Cl4N2
CAS Number:
Molecular Weight:
269.94
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
222-713-8
MDL number:
Assay:
95%
InChI key
SIZGSKQSWJIWFP-UHFFFAOYSA-N
InChI
1S/C8H4Cl4N2/c9-4-1-2-5-6(3-4)14-7(13-5)8(10,11)12/h1-3H,(H,13,14)
SMILES string
Clc1ccc2[nH]c(nc2c1)C(Cl)(Cl)Cl
assay
95%
mp
223-224 °C (dec.) (lit.)
General description
The effect of 5-chloro-2-trichloromethyl benzimidazole on binding affinity of human growth hormone (hGH) (Thr175 → Gly–hGH) to the extracellular domain of the hGH receptor (Trp104 → Gly–hGHbp) has been investigated.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Regulatory Information
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Z Guo et al.
Science (New York, N.Y.), 288(5473), 2042-2045 (2000-06-17)
Mutations introduced into human growth hormone (hGH) (Thr175 --> Gly-hGH) and the extracellular domain of the hGH receptor (Trp104 --> Gly-hGHbp) created a cavity at the protein-protein interface that resulted in binding affinity being reduced by a factor of 10(6).
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