193984
1-Methylindole
≥97%
Synonym(s):
NSC 212534
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About This Item
Empirical Formula (Hill Notation):
C9H9N
CAS Number:
Molecular Weight:
131.17
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
210-057-5
Beilstein/REAXYS Number:
111026
MDL number:
Assay:
≥97%
Form:
liquid
assay
≥97%
form
liquid
refractive index
n20/D 1.606 (lit.)
bp
133 °C/26 mmHg (lit.)
density
1.051 g/mL at 20 °C (lit.)
SMILES string
Cn1ccc2ccccc12
InChI
1S/C9H9N/c1-10-7-6-8-4-2-3-5-9(8)10/h2-7H,1H3
InChI key
BLRHMMGNCXNXJL-UHFFFAOYSA-N
General description
1-Methylindole undergoes Au(III)/TPPMS-catalyzed benzylation reaction with benzhydryl and benzylic alcohols.
Application
1-Methylindole was used in the determination of association constant for the electron-donor-acceptor complexes of 1-methylindole with 1-(2,4,6-trinitrophenyl) propan-2-one.
Reactant for preparation of:
- Pharmaceutically active 2-oxo-1-pyrrolidine analogues
- Non-receptor tyrosine kinase (Src kinase) inhibitors
- PET agents for imaging of protein kinase C (PKC)
- Ynediones as highly reactive Michael systems
- Anticancer agents
- Polycyclic derivatives of indoles
- PET agents for imaging of glycogen synthase kinase-3 (GSK-3)
- Anti-prion disease agents
- Bisindole derivatives with antihyperlipidemic activity
- PET cancer imaging agents
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Nicholas R Deprez et al.
Journal of the American Chemical Society, 128(15), 4972-4973 (2006-04-13)
This communication describes the rational development of a PdII-catalyzed method for the direct 2-arylation of indoles using [Ar-IIII-Ar]BF4. These reactions proceed under remarkably mild conditions (often at room temperature and in the presence of ambient air and moisture), and these
Benjamin S Lane et al.
Journal of the American Chemical Society, 127(22), 8050-8057 (2005-06-02)
We have recently developed palladium-catalyzed methods for direct arylation of indoles (and other azoles) wherein high C-2 selectivity was observed for both free (NH)-indole and (NR)-indole. To provide a rationale for the observed selectivity ("nonelectrophilic" regioselectivity), mechanistic studies were conducted
Martin G Banwell et al.
Organic letters, 8(21), 4959-4961 (2006-10-06)
[reaction: see text] Reaction of N-methylindole (4) with 6,6-dibromobicyclo[3.1.0]hexane (5) in the presence of silver tetrafluoroborate affords conjugate 7 in 67% yield. This product can be readily elaborated to compounds 12b and 13b which embody the polycyclic frameworks associated with
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 193984-25G | 04061838760999 |
| 193984-5G | 04061838761002 |