205206
2-Amino-5-bromo-6-methyl-4-pyrimidinol
97%
Synonym(s):
5-Bromo-6-methylisocytosine
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About This Item
Empirical Formula (Hill Notation):
C5H6BrN3O
CAS Number:
Molecular Weight:
204.02
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
228-623-5
MDL number:
Assay:
97%
InChI key
ADLWOFHKMXUDKF-UHFFFAOYSA-N
InChI
1S/C5H6BrN3O/c1-2-3(6)4(10)9-5(7)8-2/h1H3,(H3,7,8,9,10)
SMILES string
Cc1nc(N)nc(O)c1Br
assay
97%
mp
244-246 °C (lit.)
functional group
bromo
General description
2-Amino-5-bromo-6-methyl-4-pyrimidinol induced high levels of serum interferon in mice.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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P S Morahan et al.
Antiviral research, 15(3), 241-254 (1991-03-01)
The question of whether interferon alpha/beta is the common mechanism of antiviral action of synthetic immunomodulators was investigated in B6C3F1 mice infected with Semliki Forest virus. Mice were treated with various concentrations of normal sheep serum or potent anti-alpha/beta interferon
L S Anthony et al.
Clinical and investigative medicine. Medecine clinique et experimentale, 7(4), 343-348 (1984-01-01)
The modulation of murine host resistance to infection with Listeria monocytogenes by the substituted pyrimidine anti-viral compounds, 2-amino-5-bromo-6-methyl-4-pyrimidinol (ABMP), 2-amino-5-bromo-6-phenyl-4-pyrimidinol (ABPP) and 2-amino-5-iodo-6-phenyl-4-pyrimidinol (AIPP) was investigated. BAF1 mice given three daily injections of ABMP, ABPP (as well as of the
D A Stringfellow
Antimicrobial agents and chemotherapy, 11(6), 984-992 (1977-06-01)
2-Amino-5-bromo-6-methyl-4-pyrimidinol (U-25,166), polyinosinic acid-polycytidylic acid [poly(I:C)], and tilorone HCl induced high levels of serum interferon in mice. Each consequently protected mice against infection with several viruses. After daily injection of inducer, mice developed a reduced interferon response (hyporeactivity) to each
D A Stringfellow et al.
Journal of interferon research, 1(1), 1-14 (1980-01-01)
The interferon inducing characteristics of a new series of 6-phenyl pyrimidinol compounds are described and compared against a previously identified pyrimidine, 2-amino-5-bromo-6-methyl-4-pyrimidinol (ABMP). Interestingly, a split in ability to induce interferon but not in vivo antiviral activity was observed in
D A Stringfellow
Antimicrobial agents and chemotherapy, 17(3), 455-460 (1980-03-01)
Prostaglandins enhanced the interferon response and therapeutic activity of interferon inducers in Friend leukemia virus-infected mice. A similar enhancement in interfron responsiveness but not antiviral activity was observed in mice infected with rapidly acute viruses.
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