206490
4-Ethynylanisole
97%
Synonym(s):
1-Ethynyl-4-methoxybenzene
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About This Item
Linear Formula:
CH3OC6H4C≡CH
CAS Number:
Molecular Weight:
132.16
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
97%
Form:
solid
Quality Segment
assay
97%
form
solid
refractive index
n
bp
87-91 °C/11 mmHg (lit.)
mp
28-29 °C (lit.)
density
1.019 g/mL at 25 °C (lit.)
SMILES string
COc1ccc(cc1)C#C
InChI
1S/C9H8O/c1-3-8-4-6-9(10-2)7-5-8/h1,4-7H,2H3
InChI key
KBIAVTUACPKPFJ-UHFFFAOYSA-N
General description
4-Ethynylanisole forms the corresponding propargyl aldehyde in good yield directly from DMF-dimethyl acetal without the need for making an acetylide salt. 1,3-dipolar cycloaddition of acceptor-cyclopropylmethylsilanes affords functionalized cyclopentenes in good yields.
4-Ethynylanisole can be used as a building block in organic synthesis and also used in sonogashira coupling reactions.
4-Ethynylanisole can be used as a building block in organic synthesis and also used in sonogashira coupling reactions.
Application
Forms the corresponding propargyl aldehyde in good yield directly from DMF-dimethyl acetal without the need for making an acetylide salt.
1,3-dipolar cycloaddition of acceptor-cyclopropylmethylsilanes affords functionalized cyclopentenes in good yields.
4-Ethynylanisole was used:
- in the synthesis of photoluminescent 1,2-dihydrophosphinines via a [4 + 2] cycloaddition
- along with an arylboronic acid and sodium azide in a copper-catalyzed, three-component synthesis of trisubstituted 1,2,4-triazoles
- in a study of a gold (III)-catalyzed hydroamination of alkynes leading to N-vinylindoles.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
179.6 °F - closed cup
flash_point_c
82 °C - closed cup
ppe
Eyeshields, Gloves, type N95 (US)
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