208884
Urea
reagent grade, 98%
Synonym(s):
Carbamide, Carbonyldiamide
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About This Item
Linear Formula:
NH2CONH2
CAS Number:
Molecular Weight:
60.06
EC Number:
200-315-5
UNSPSC Code:
12352100
MDL number:
Beilstein/REAXYS Number:
635724
grade
reagent grade
assay
98%
mp
132-135 °C (lit.)
density
1.335 g/mL at 25 °C (lit.)
SMILES string
NC(N)=O
InChI
1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)
InChI key
XSQUKJJJFZCRTK-UHFFFAOYSA-N
Application
Used for the denaturation of proteins and as a mild solubilization agent for insoluble or denatured proteins. Useful for renaturing proteins from samples already denatured with 6 M guanidine chloride such as inclusion bodies. May be used with guanidine hydrochloride and dithiothreitrol (DTT) in the refolding of denatured proteins into their native or active form.
Other Notes
This product has been replaced by U1250-Sigma-Aldrich | Urea, ReagentPlus®, ≥99.5%, pellets | NH2CONH2
Legal Information
ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Frederik B Pruijn et al.
Journal of medicinal chemistry, 48(4), 1079-1087 (2005-02-18)
The extravascular diffusion of antitumor agents is a key determinant of their therapeutic activity, but the relationships between physicochemical properties of drugs and their extravascular transport are poorly understood. It is well-known that drug lipophilicity plays an important role in
Lei Du-Cuny et al.
Bioorganic & medicinal chemistry, 17(19), 6983-6992 (2009-09-08)
Computational modeling continues to play an important role in novel therapeutics discovery and development. In this study, we have investigated the use of in silico approaches to develop inhibitors of the pleckstrin homology (PH) domain of AKT (protein kinase B).
Alex Avdeef et al.
Journal of medicinal chemistry, 53(9), 3566-3584 (2010-04-09)
The study aimed to predict effective human jejunal permeability (P(eff)) using a biophysical model based on parametrized paracellular, aqueous boundary layer, and transcellular permeabilities, and the villus-fold surface area expansion factor (k(VF)). Published human jejunal data (119 P(eff), 53 compounds)