211222
Boron tribromide solution
1.0 M in methylene chloride
Synonym(s):
Tribromoboron
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About This Item
Empirical Formula (Hill Notation):
BBr3
CAS Number:
Molecular Weight:
250.52
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352101
MDL number:
Form:
liquid
form
liquid
Quality Level
concentration
1.0 M in methylene chloride
density
1.467 g/mL at 25 °C
SMILES string
BrB(Br)Br
InChI
1S/BBr3/c2-1(3)4
InChI key
ILAHWRKJUDSMFH-UHFFFAOYSA-N
General description
Boron tribromide (BBr3) is a commonly used reagent in organic chemistry for demethylation.
Application
Used to cleave aryl methyl ethers in a synthesis of a benzopyranobenzopyran from a coumarin scaffold.
Reactant for preparation of:
- Drug intermediate 6-nitro-L-DOPA
- Luminescent polystyrene derivatives with sterically protected carbazolylborane moieties
- High-quality boron-doped graphene via Wurtz-type reductive coupling reaction
- Mercapto-(+)-methamphetamine haptens for synthesis of (+)-methamphetamine conjugate vaccines with improved epitope densities
- Micrometer-sized organic molecule-DNA hybrid structures
- Borane complexes via electrophilic aromatic borylation reactions
- A 5-HT2C receptor agonist
- Biphenyl-derivatives possessing tertiary amino groups as β-secretase(BACE1) inhibitors for the treatment of Alzheimer′s disease
- A highly near-IR region fluorescent p-extended boron aza-dipyrromethene moiety unit
- Tetrahydroisoquinoline derivatives via intramolecular cyclization of methoxy-substituted N-phenethylimides
Packaging
The 25 mL Sure/Seal™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.
Legal Information
Sure/Seal is a trademark of Sigma-Aldrich Co. LLC
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Danger
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Skin Corr. 1A - STOT SE 3
target_organs
Central nervous system
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Regulatory Information
危险化学品
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Azobenzene derivatives show anti-cancer activity against pancreatic cancer cells only under nutrient starvation conditions via G0/G1 cell cycle arrest
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Tetrahedron, 85, 132077-132077 (2021)
Tetrahedron Letters, 47, 5909-5909 (2006)
Hui Wang et al.
European journal of medicinal chemistry, 88, 66-73 (2014-09-14)
The pharmacokinetics (PK) and pharmacodynamics (PD) of PT119, a potent Staphylococcus aureus enoyl-ACP reductase (saFabI) inhibitor with a Ki value of 0.01 nM and a residence time of 750 min on the enzyme target, has been evaluated in mice. PT119
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 211222-10ML | 04061838125514 |
| 211222-4X25ML | 04061838771650 |
| 211222-PZ | 04061823808620 |
| 211222-100ML | 04061838771643 |
| 211222-2L | 04061838125521 |
| 211222-800ML | 04061838771667 |