218898
5-(Dimethylamino)-1-naphthalenesulfonamide
99%
Synonym(s):
DNSA, Dansyl amide
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About This Item
Linear Formula:
(CH3)2NC10H6SO2NH2
CAS Number:
Molecular Weight:
250.32
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
215-854-1
Beilstein/REAXYS Number:
2217203
MDL number:
Assay:
99%
Quality Level
assay
99%
mp
218-221 °C (lit.)
fluorescence
λex 280 nm; λem 470 nm (bound to carbon anhydrase), λem 580 in ethanol
functional group
amine
SMILES string
CN(C)c1cccc2c(cccc12)S(N)(=O)=O
InChI
1S/C12H14N2O2S/c1-14(2)11-7-3-6-10-9(11)5-4-8-12(10)17(13,15)16/h3-8H,1-2H3,(H2,13,15,16)
InChI key
TYNBFJJKZPTRKS-UHFFFAOYSA-N
Application
5-(Dimethylamino)-1-naphthalenesulfonamide (DNSA) was used as starting reagent in the synthesis of 2,6-disubstituted pyridines, 6-substituted 2,2′-bipyridines and 6,6′-disubstituted 2,2′-bipyridines. It was also used as fluorescent probe in the determination of concentration of human carbonic anhydrase II-DNSA in solutions.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Raymond Ziessel et al.
Organic letters, 5(14), 2397-2400 (2003-07-05)
[structure: see text] 2,6-Disubstituted pyridines, 6-substituted 2,2'-bipyridines, and 6,6'-disubstituted 2,2'-bipyridines are readily prepared under mild conditions from 5-(dimethylamino)-1-naphthalenesulfonamide chloride (DANS-Cl) and chloromethyl-nitronyl nitroxide (CH(2)Cl-NIT) starting materials and adequately functionalized building blocks. The syntheses of the pyridine molecules bearing two radicals
K Yamasaki et al.
Biochimica et biophysica acta, 1432(2), 313-323 (1999-07-17)
The relationship between the two principal ligand binding sites, sites I and II, on human serum albumin (HSA) was quantitatively and qualitatively examined by equilibrium dialysis and fluorescence spectroscopy. Among the three subsite markers to site I, only the binding
Konstantinos Kavallieratos et al.
Journal of the American Chemical Society, 127(18), 6514-6515 (2005-05-05)
The (bis)dansylated sulfonamide 1,2-C6H4(NHSO2C10H6-5-N(CH3)2)2 (1) extracted Pb(II) selectively from water into 1,2-dichloroethane via an ion-exchange mechanism and showed fluorescence quenching upon Pb(II) extraction. The distribution ratios for metal extraction (determined by ICP-MS) for Pb(II) were 133-1410 times higher than those
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 218898-1G | 04061838775719 |