219835
2-Hydroxy-3-methylbutyric acid
99%
Synonym(s):
2-Hydroxyisovaleric acid
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About This Item
Linear Formula:
(CH3)2CHCH(OH)CO2H
CAS Number:
Molecular Weight:
118.13
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
223-697-5
MDL number:
Assay:
99%
Form:
solid
Quality Level
assay
99%
form
solid
mp
86-87 °C (lit.)
functional group
carboxylic acid, hydroxyl
SMILES string
CC(C)C(O)C(O)=O
InChI
1S/C5H10O3/c1-3(2)4(6)5(7)8/h3-4,6H,1-2H3,(H,7,8)
InChI key
NGEWQZIDQIYUNV-UHFFFAOYSA-N
General description
Chiral resolution of 2-hydroxy-3-methylbutyric acid without derivatization has been studied by capillary electrophoresis using 2-hydroxypropyl-β-cyclodextrin.
Application
2-Hydroxy-3-methylbutyric acid was employed as internal standard for analysis of ethylene glycol (EG) and γ-hydroxybutyrate (GHB) in whole blood.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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S Landaas et al.
Clinica chimica acta; international journal of clinical chemistry, 78(3), 489-493 (1977-08-01)
Examination of urine samples by capillary column gas chromatography and mass spectrometry showed the presence of 2-hydroxyisovaleric acid together with trace amounts of the three branched-chain 2-keto acids in five patients with lactic and ketoacidosis. None of these compounds was
F Magni et al.
Analytical biochemistry, 220(2), 308-314 (1994-08-01)
A sensitive method for the simultaneous analysis of plasma alpha-ketoisocaproic acid (KIC) and leucine using GC-MS is described. Plasma was deproteinized after addition of both alpha-ketovaleric acid and norleucine as internal standards. Derivatization of the compounds involved protection of the
Direct chiral resolution of aliphatic a-hydroxy acids using 2-hydroxypropyl-?-cyclodextrin in capillary electrophoresis.
Kodama S, et al.
Analyst, 124(1), 55-59 (1999)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 219835-1G | 04061838776129 |