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220590

Sodium orthovanadate

Name: Sodium orthovanadate
Brand: ALDRICH

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About This Item

Linear Formula:

Na₃VO₄

CAS Number:

13721-39-6

Molecular Weight:

183.91

EC Number:

237-287-9

UNSPSC Code:

12352103

MDL number:

MFCD00003511

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Properties

mp

850-866 °C (lit.)

SMILES string

[Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O

InChI

1S/3Na.4O.V/q3*+1;;3*-1;

InChI key

IHIXIJGXTJIKRB-UHFFFAOYSA-N

Description

Application

Agent used in the study of diabetes.

Biochem/physiol Actions

Inhibits ATPase, alkaline phosphatase and tyrosine phosphatase. Decavanadate, which is formed at acidic pH, inhibits inositol 1,4,5-trisphosphate (IP₃)-induced Ca²⁺ release from endocrine cells and blocks IP₃ binding to its receptor in brain tissue.

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Vanadate treatment restores the expression of genes for key enzymes in the glucose and ketone bodies metabolism in the liver of diabetic rats.

A Valera et al.

The Journal of clinical investigation, 92(1), 4-11 (1993-07-01)

Oral administration of vanadate to diabetic streptozotocin-treated rats decreased the high blood glucose and D-3-hydroxybutyrate levels related to diabetes. The increase in the expression of the P-enolpyruvate carboxykinase (PEPCK) gene, the main regulatory enzyme of gluconeogenesis, was counteracted in the