222798
N-Methylbenzamide
≥99%
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About This Item
Linear Formula:
C6H5CONHCH3
CAS Number:
Molecular Weight:
135.16
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
210-362-3
MDL number:
Assay:
≥99%
Form:
solid
assay
≥99%
form
solid
bp
167 °C/11 mmHg (lit.)
mp
76-78 °C (lit.)
solubility
ethanol: soluble 50 mg/mL, clear, yellow-green
functional group
amide, phenyl
SMILES string
CNC(=O)c1ccccc1
InChI
1S/C8H9NO/c1-9-8(10)7-5-3-2-4-6-7/h2-6H,1H3,(H,9,10)
InChI key
NCCHARWOCKOHIH-UHFFFAOYSA-N
General description
N-Methylbenzamide is a potent PDE10A (phosphodiesterase with a remarkable localization as the protein is abundant only in brain tissue) inhibitor.
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H van de Waterbeemd et al.
Journal of medicinal chemistry, 29(5), 600-606 (1986-05-01)
The electronic properties of orthopramides, a group of selective D-2 dopamine receptor antagonists, were investigated by calculating molecular electrostatic potentials (MEP) of model compounds with the ab initio STO-3G MO method. The various substitution patterns of the aromatic ring are
Atsushi Satoh et al.
Bioorganic & medicinal chemistry letters, 19(18), 5464-5468 (2009-08-14)
We identified 4-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide 27 as a potent mGluR1 antagonist. The compound possessed excellent subtype selectivity and good PK profile in rats. It also demonstrated relatively potent antipsychotic-like effects in several animal models. Suitable for development as a PET tracer, compound
L Constantino et al.
Biochemical pharmacology, 44(4), 651-658 (1992-08-18)
The metabolism of N,N-dimethylbenzamides by phenobarbital-induced rat liver microsomes results in the formation of N-methylbenzamides and formaldehyde. The reaction proceeds via the formation of an intermediate N-hydroxymethyl-N-methylbenzamide, which, for the microsomal oxidation of N,N-dimethylbenzamide, was isolated and characterized. Confirmation of
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 222798-10G | 04061831810165 |
| 222798-5G | 04061831810172 |