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Merck
CN

222984

Propranolol hydrochloride

99%

Synonym(s):

1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride

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About This Item

Linear Formula:
C10H7OCH2CH(OH)CH2NHCH(CH3)2·HCl
CAS Number:
318-98-9
Molecular Weight:
295.80
UNSPSC Code:
12352200
PubChem Substance ID:
329752297
EC Number:
206-268-7
MDL number:
MFCD00012558

Key Documents

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InChI key

ZMRUPTIKESYGQW-UHFFFAOYSA-N

InChI

1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H

SMILES string

Cl[H].CC(C)NCC(O)COc1cccc2ccccc12

assay

99%

mp

163-165 °C (lit.)

Gene Information

human ... ADRB1(153), ADRB2(154)

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

监管及禁止进口产品
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Certificates of Analysis (COA)

Lot/Batch Number
07528HH
S40526
16524AH
18517DE
12704AE

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. Which enantiomer, if any, relates to Product 222984, Propranolol hydrochloride?

    Although no optical rotation testing is done on this product, we would expect that this is a racemic mixture.

  4. What is Product 222984, Propranolol hydrochloride, soluble in?

    Based on our own quality control testing, we find that the product is soluble in water at 50 mg/mL. Aqueous solutions of propranolol are most stable at pH 3. Propranolol decomposes rapidly under alkaline conditions. The decomposition is often exhibited as a discoloration of the solution. According to the chemicals encyclopedia published by the Royal Society of Chemistry, this is also expected to be soluble in alcohols. It is practically insoluble in ether, benzene and ethyl acetate.

  5. Where can I find more information and references to the biochemical actions of Product 222984, Propranolol hydrochloride?

    There is a product datasheet and an review of beta-adrenoceptors on the product webpage for similar listing, Product No. P0884.

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Terril L Verplaetse et al.
Psychopharmacology, 232(15), 2647-2657 (2015-03-07)
Evidence suggests that the noradrenergic system mediates ethanol reinforcement. However, preclinical studies suggest that noradrenergic antagonists block other oral reinforcers indicating possible unwanted secondary medication effects. This study examined combinations of low-dose prazosin with propranolol or naltrexone using a behavioral
Geoffrey H Tofler et al.
The American journal of cardiology, 111(12), 1755-1758 (2013-04-09)
Heavy physical exertion, emotional stress, heavy meals, and respiratory infection transiently increase the risk of myocardial infarction, sudden cardiac death, and stroke; however, it remains uncertain how to use this information for disease prevention. We determined whether it was feasible
Luca Filippi et al.
The Journal of pediatrics, 163(6), 1570-1577 (2013-09-24)
To evaluate safety and efficacy of oral propranolol administration in preterm newborns affected by an early phase of retinopathy of prematurity (ROP). Fifty-two preterm newborns with Stage 2 ROP were randomized to receive oral propranolol (0.25 or 0.5 mg/kg/6 hours)
Nicole D Powell et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(41), 16574-16579 (2013-09-26)
Across a variety of adverse life circumstances, such as social isolation and low socioeconomic status, mammalian immune cells have been found to show a conserved transcriptional response to adversity (CTRA) involving increased expression of proinflammatory genes. The present study examines
Philip M Short et al.
American journal of respiratory and critical care medicine, 187(12), 1308-1314 (2013-04-19)
Unblinded studies have shown improvements in airway hyperresponsiveness with chronic nadolol in steroid-naive patients with asthma. To assess the effects of chronic nonselective β-blockade as add-on to inhaled corticosteroids (ICS) in patients with asthma. A double-blind randomized placebo-controlled crossover trial
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