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224952

1-Piperonylpiperazine

Name: 1-Piperonylpiperazine
Brand: ALDRICH

97%

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₆N₂O₂

CAS Number:

32231-06-4

Molecular Weight:

220.27

NACRES:

NA.22

PubChem Substance ID:

24853467

UNSPSC Code:

12352100

EC Number:

250-968-5

MDL number:

MFCD00005834

Assay:

97%

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Properties

Quality Level

100

assay

97%

bp

147-149 °C/2 mmHg (lit.)

mp

36-40 °C (lit.)

SMILES string

C1CN(CCN1)Cc2ccc3OCOc3c2

InChI

1S/C12H16N2O2/c1-2-11-12(16-9-15-11)7-10(1)8-14-5-3-13-4-6-14/h1-2,7,13H,3-6,8-9H2

InChI key

NBOOZXVYXHATOW-UHFFFAOYSA-N

Description

General description

The effect of 1-piperonylpiperazine on 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity was studied.

Application

1-Piperonylpiperazine was used in the synthesis of acetyl-caffeic acid-1-piperonylpiperazine (HBU-47).

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Antagonism of 3,4-methylenedioxymethamphetamine-induced neurotoxicity in rat brain by 1-piperonylpiperazine.

K Hashimoto et al.

European journal of pharmacology, 228(2-3), 171-174 (1992-09-01)

The effects of 1-piperonylpiperazine and N,alpha-dimethylpiperonylamine, which are weak inhibitors for [3H]5-hydroxytryptamine (5-HT) uptake, on 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity were examined. The reductions of serotonergic parameters in the rat cerebral cortex produced by multiple administration of MDMA (10 mg/kg) were attenuated

A novel caffeic acid-1-piperonylpiperazine hybridization compound HBU-47 inhibits LPS-mediated inflammation in RAW264.7 macrophage cells.

Seon-Young Park et al.

International immunopharmacology, 19(1), 60-65 (2013-12-24)

In the present study, we synthesized a new hybrid compound by coupling caffeic acid and 1-piperonylpiperazine. The synthetic compound, acetyl-caffeic acid-1-piperonylpiperazine (HBU-47), showed potent anti-inflammatory effects inhibiting lipopolysaccharide (LPS)-induced production of nitric oxide (NO) in RAW264.7 macrophage cells. HBU-47 inhibited

Pooled human liver preparations, HepaRG, or HepG2 cell lines for metabolism studies of new psychoactive substances? A study using MDMA, MDBD, butylone, MDPPP, MDPV, MDPB, 5-MAPB, and 5-API as examples.

Lilian H J Richter et al.

Journal of pharmaceutical and biomedical analysis, 143, 32-42 (2017-06-12)

Metabolism studies play an important role in clinical and forensic toxicology. Because of potential species differences in metabolism, human samples are best suitable for elucidating metabolism. However, in the case of new psychoactive substances (NPS), human samples of controlled studies

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Global Trade Item Number

SKU	GTIN
224952-25G	04061833313305