225525
2-Amino-2-norbornanecarboxylic acid
98%
Synonym(s):
2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid
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About This Item
Empirical Formula (Hill Notation):
C8H13NO2
CAS Number:
Molecular Weight:
155.19
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C8H13NO2/c9-8(7(10)11)4-5-1-2-6(8)3-5/h5-6H,1-4,9H2,(H,10,11)/t5-,6+,8?/m1/s1
SMILES string
NC1(C[C@@H]2CC[C@H]1C2)C(O)=O
InChI key
MPUVBVXDFRDIPT-RSHNMJPRSA-N
assay
98%
mp
>300 °C (lit.)
Application
Inhibitor of amino acid transport across cell membranes.
Regulatory Information
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Kohichi Yamauchi et al.
Cancer letters, 276(1), 95-101 (2008-12-09)
LAT1, a subunit of heterodimeric system L transporter responsible for transporting neutral amino acids into cells, has been investigated in several cancers because of its onco-fetal nature. Based on the studies of its functional inhibition, LAT1 has been proposed to
M M Sánchez del Pino et al.
The Journal of biological chemistry, 267(36), 25951-25957 (1992-12-25)
Endothelial cell membranes, the site of the blood-brain barrier, were obtained from the capillaries of cow brain. The luminal and abluminal membranes were separated by centrifugation on a discontinuous Ficoll gradient. Electron microscopy revealed that the membrane preparations consisted almost
Jordan A Torok et al.
American journal of respiratory cell and molecular biology, 47(1), 37-43 (2012-02-11)
Inhaled nitric oxide (iNO) is used to treat pulmonary hypertension and is being investigated for prevention of bronchopulmonary dysplasia in neonates. Extrapulmonary effects of iNO are widely recognized, but the underlying chemistry and pharmacology are poorly understood. Growing evidence suggests
Ashwini L Chand et al.
Human reproduction (Oxford, England), 26(11), 3102-3108 (2011-09-15)
Little is known about metabolic processes in the developing ovarian follicle. Using mouse ovarian follicles, we investigated uptake of L-leucine by follicles at varying stages of maturity in the presence of insulin-like growth factor (IGF)-1. METHODS Mouse ovarian follicles were
Seung Jin Han et al.
The Journal of endocrinology, 212(3), 307-315 (2011-12-02)
2-Aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH) is an activator of glutamate dehydrogenase (GDH), which is a mitochondrial enzyme with an important role in insulin secretion. We investigated the effect of BCH on the high-glucose (HG)-induced reduction in glucose-stimulated insulin secretion (GSIS), the HG/palmitate
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