225525
2-Amino-2-norbornanecarboxylic acid
98%
Synonym(s):
2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid
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About This Item
Empirical Formula (Hill Notation):
C8H13NO2
CAS Number:
Molecular Weight:
155.19
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Assay
98%
mp
>300 °C (lit.)
SMILES string
NC1(C[C@@H]2CC[C@H]1C2)C(O)=O
InChI
1S/C8H13NO2/c9-8(7(10)11)4-5-1-2-6(8)3-5/h5-6H,1-4,9H2,(H,10,11)/t5-,6+,8?/m1/s1
InChI key
MPUVBVXDFRDIPT-RSHNMJPRSA-N
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Application
Inhibitor of amino acid transport across cell membranes.
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M M Sánchez del Pino et al.
The Journal of biological chemistry, 267(36), 25951-25957 (1992-12-25)
Endothelial cell membranes, the site of the blood-brain barrier, were obtained from the capillaries of cow brain. The luminal and abluminal membranes were separated by centrifugation on a discontinuous Ficoll gradient. Electron microscopy revealed that the membrane preparations consisted almost
Kohichi Yamauchi et al.
Cancer letters, 276(1), 95-101 (2008-12-09)
LAT1, a subunit of heterodimeric system L transporter responsible for transporting neutral amino acids into cells, has been investigated in several cancers because of its onco-fetal nature. Based on the studies of its functional inhibition, LAT1 has been proposed to
Hisao Imai et al.
Anticancer research, 30(12), 4819-4828 (2010-12-29)
L-type amino acid transporter 1 (LAT1) is highly expressed in various human neoplasms. Antitumor activity of inhibiting LAT1 was analyzed in non-small cell lung cancer (NSCLC). Expression of LAT1 mRNA in 54 lung cancer cell lines was examined by RT-PCR.
L E Kerper et al.
The American journal of physiology, 262(5 Pt 2), R761-R765 (1992-05-01)
The mechanism by which methylmercury (MeHg) crosses the blood-brain barrier was examined in the rat. Previous studies demonstrated that intravenous injection of L-cysteine with MeHg accelerates MeHg uptake into brain. Since the complex of MeHg with L-cysteine is structurally similar
Sheng Li et al.
American journal of physiology. Cell physiology, 292(4), C1263-C1271 (2006-11-10)
System L amino acid transporters have been shown to be responsible for cellular uptake of S-nitroso-L-cysteine (l-CSNO). In this study, we examined the characteristics of L-CSNO uptake in Xenopus laevis oocytes expressing system L transporters and found that uptake increased
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