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1,2-Naphthoquinone-4-sulfonic acid sodium salt

Name: 1,2-Naphthoquinone-4-sulfonic acid sodium salt
Brand: ALDRICH

97%

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Synonym(s):

3,4-Dihydro-3,4-dioxo-1-naphthalenesulfonic acid sodium salt, Folin’s reagent, Sodium 1,2-naphthoquinone-4-sulfonate

Empirical Formula (Hill Notation):

C₁₀H₅NaO₅S

CAS Number:

521-24-4

Molecular Weight:

260.20

Beilstein:

4169788

EC Number:

208-308-9

MDL number:

MFCD00001700

PubChem Substance ID:

24853538

NACRES:

NA.22

Assay

97%

form

powder

mp

289 °C (dec.) (lit.)

solubility

alcohol: slightly soluble 95%
acetone: moderately soluble(lit.)
benzene: insoluble(lit.)
carbon disulfide: insoluble(lit.)
chloroform: insoluble(lit.)
diethyl ether: insoluble(lit.)
petroleum ether: insoluble(lit.)
water: soluble(lit.)

SMILES string

[Na+].[O-]S(=O)(=O)C1=CC(=O)C(=O)c2ccccc12

InChI

1S/C10H6O5S.Na/c11-8-5-9(16(13,14)15)6-3-1-2-4-7(6)10(8)12;/h1-5H,(H,13,14,15);/q;+1/p-1

InChI key

UBLXEEBHYISRFM-UHFFFAOYSA-M

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Application

1,2-Naphthoquinone-4-sulfonic acid sodium salt (Folin′s reagent) was used in the colorimetric assay for determination of procaine hydrochloride in pharmaceutical preparations.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Colorimetric determination of procaine hydrochloride in pharmaceutical preparations.

R B Salama et al.

Journal of pharmaceutical sciences, 69(3), 346-348 (1980-03-01)

A new rapid, specific, and convenient colorimetric method for the determination of procaine hydrochloride in pharmaceutical preparations is described. This method is based on measurement of the intensity of the orange-red color developed when procaine hydrochloride is allowed to react

Spectrophotometric study for the reaction between fluvoxamine and 1,2-naphthoquinone-4-sulphonate: Kinetic, mechanism and use for determination of fluvoxamine in its dosage forms.

Ibrahim A Darwish et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 72(4), 897-902 (2009-01-13)

Spectrophotometric study was carried out, for the first time, to investigate the reaction between the antidepressant fluvoxamine (FXM) and 1,2-naphthoquinone-4-sulphonate (NQS) reagent. In alkaline medium (pH 9), an orange-colored product exhibiting maximum absorption peak (lambda(max)) at 470nm was produced. The

Capillary electrophoresis determination of biogenic amines by field-amplified sample stacking and in-capillary derivatization.

Natividad García-Villar et al.

Electrophoresis, 27(2), 474-483 (2005-12-07)

A sensitive CE method for determining biogenic amines in wines based on in-capillary derivatization with 1,2-naphthoquinone-4-sulfonate is presented. In this method, reagent and buffer solutions are introduced hydrodynamically into the capillary whereas the sample is injected electrokinetically, thus, allowing a

Derivatization strategies for the determination of biogenic amines in wines by chromatographic and electrophoretic techniques.

Santiago Hernández-Cassou et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(17-18), 1270-1281 (2010-12-28)

This paper revises the derivatization approaches for the determination of biogenic amines in wines. Since most of these amines display poor spectroscopic features to be detected by UV absorption or emission (fluorescence) spectroscopy, derivatization is necessary to attain the desired

Spectrophotometric determination of dapsone in pharmaceutical products using sodium 1,2-naphthoquinone-4-sulfonic as the chromogenic reagent.

Huai You Wang et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 60(12), 2933-2939 (2004-09-08)

Spectrophotometric determination of dapsone is described. The dapsone reacts with sodium 1,2-naphthoquinone-4-sulfonic in pH 6.98 buffer solution to form a salmon pink compound, and its maximum absorption wavelength is at 525 nm, epsilon525=3.68 x 10(4) l mol(-1) cm(-1). The absorbance

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