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Merck
CN

226017

1,2-Naphthoquinone-4-sulfonic acid sodium salt

97%

Synonym(s):

3,4-Dihydro-3,4-dioxo-1-naphthalenesulfonic acid sodium salt, Folin’s reagent, Sodium 1,2-naphthoquinone-4-sulfonate

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About This Item

Empirical Formula (Hill Notation):
C10H5NaO5S
CAS Number:
521-24-4
Molecular Weight:
260.20
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24853538
EC Number:
208-308-9
Beilstein/REAXYS Number:
4169788
MDL number:
MFCD00001700
Assay:
97%
Form:
powder

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InChI key

UBLXEEBHYISRFM-UHFFFAOYSA-M

InChI

1S/C10H6O5S.Na/c11-8-5-9(16(13,14)15)6-3-1-2-4-7(6)10(8)12;/h1-5H,(H,13,14,15);/q;+1/p-1

SMILES string

[Na+].[O-]S(=O)(=O)C1=CC(=O)C(=O)c2ccccc12

assay

97%

form

powder

mp

289 °C (dec.) (lit.)

solubility

alcohol: slightly soluble 95%, acetone: moderately soluble(lit.), benzene: insoluble(lit.), carbon disulfide: insoluble(lit.), chloroform: insoluble(lit.), diethyl ether: insoluble(lit.), petroleum ether: insoluble(lit.), water: soluble(lit.)

functional group

ketone, sulfonic acid

Quality Level

100

Related Categories

Application

1,2-Naphthoquinone-4-sulfonic acid sodium salt (Folin′s reagent) was used in the colorimetric assay for determination of procaine hydrochloride in pharmaceutical preparations.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN8457
BCCN7823
BCCM7597
BCCM7443
BCCM7598

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R B Salama et al.
Journal of pharmaceutical sciences, 69(3), 346-348 (1980-03-01)
A new rapid, specific, and convenient colorimetric method for the determination of procaine hydrochloride in pharmaceutical preparations is described. This method is based on measurement of the intensity of the orange-red color developed when procaine hydrochloride is allowed to react
Ibrahim A Darwish et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 72(4), 897-902 (2009-01-13)
Spectrophotometric study was carried out, for the first time, to investigate the reaction between the antidepressant fluvoxamine (FXM) and 1,2-naphthoquinone-4-sulphonate (NQS) reagent. In alkaline medium (pH 9), an orange-colored product exhibiting maximum absorption peak (lambda(max)) at 470nm was produced. The
Santiago Hernández-Cassou et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(17-18), 1270-1281 (2010-12-28)
This paper revises the derivatization approaches for the determination of biogenic amines in wines. Since most of these amines display poor spectroscopic features to be detected by UV absorption or emission (fluorescence) spectroscopy, derivatization is necessary to attain the desired
Huai You Wang et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 60(12), 2933-2939 (2004-09-08)
Spectrophotometric determination of dapsone is described. The dapsone reacts with sodium 1,2-naphthoquinone-4-sulfonic in pH 6.98 buffer solution to form a salmon pink compound, and its maximum absorption wavelength is at 525 nm, epsilon525=3.68 x 10(4) l mol(-1) cm(-1). The absorbance
Sameer A M Abdulrahman et al.
Drug testing and analysis, 3(10), 748-754 (2011-02-22)
A simple, sensitive, and selective spectrophotometric method has been developed for the determination of gabapentin (GBP) in capsules. The method is based on the reaction of GBP and sodium 1,2-naphthoquinone-4-sulfonate (NQS) in the presence of Clark and Lubs buffer of
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