235296
2-(Trifluoromethyl)phenylacetic acid
98%
Synonym(s):
(α,α,α-Trifluoro-o-tolyl)acetic acid
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About This Item
Linear Formula:
CF3C6H4CH2CO2H
CAS Number:
Molecular Weight:
204.15
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
221-240-4
MDL number:
Assay:
98%
Form:
solid
Product Name
2-(Trifluoromethyl)phenylacetic acid, 98%
InChI key
TYOCDHCKTWANIR-UHFFFAOYSA-N
InChI
1S/C9H7F3O2/c10-9(11,12)7-4-2-1-3-6(7)5-8(13)14/h1-4H,5H2,(H,13,14)
SMILES string
OC(=O)Cc1ccccc1C(F)(F)F
assay
98%
form
solid
mp
100-102 °C (lit.)
functional group
carboxylic acid
fluoro
Quality Level
Related Categories
Application
2-(Trifluoromethyl)phenylacetic acid has been used in the synthesis of potential antithrombotics and lipoxygenase inhibitors.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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E S Lazer et al.
Journal of medicinal chemistry, 33(7), 1892-1898 (1990-07-01)
A series of 2,6-disubstituted 4-(2-arylethenyl)phenols with potent human neutrophil 5-lipoxygenase (5-LO) inhibiting activity (IC50S in the 10(-7) M range) and weaker human platelet cyclooxygenase (CO) inhibiting activity (IC50S in the 10(-6) M range) is described. This series evolved from the
P L Barker et al.
Journal of medicinal chemistry, 35(11), 2040-2048 (1992-05-29)
Stimulation of platelets activates GPIIbIIIa, the heterodimeric integrin receptor, to bind fibrinogen (Fg), which results in platelet aggregation. GPIIbIIIa/Fg binding inhibitors are potentially suitable for acute use during and after thrombolytic therapy as antithrombotic agents. Incorporation of the tripeptide sequence
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