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242039

1,2-Diacetylbenzene

Name: 1,2-Diacetylbenzene
Brand: ALDRICH

99%

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About This Item

Linear Formula:

C₆H₄(COCH₃)₂

CAS Number:

704-00-7

Molecular Weight:

162.19

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24854529

EC Number:

211-877-6

Beilstein/REAXYS Number:

1862907

MDL number:

MFCD00008733

Assay:

99%

Form:

solid

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Properties

Quality Level

200

assay

99%

form

solid

bp

110 °C/0.1 mmHg (lit.)

mp

39-41 °C (lit.)

solubility

dichloromethane: soluble 50 mg/mL, clear, colorless to yellow

fluorescence

λ_ex 355 nm; λ_em 455 nm (Amine adducts)

functional group

ketone

SMILES string

CC(=O)c1ccccc1C(C)=O

InChI

1S/C10H10O2/c1-7(11)9-5-3-4-6-10(9)8(2)12/h3-6H,1-2H3

InChI key

LVQFKRXRTXCQCZ-UHFFFAOYSA-N

Description

General description

1,2-Diacetylbenzene, an aromatic hydrocarbon, is a protein-reactive γ-diketone metabolite of the neurotoxic solvent 1,2-diethylbenzene.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Probing mechanisms of axonopathy. Part II: Protein targets of 2,5-hexanedione, the neurotoxic metabolite of the aliphatic solvent n-hexane.

Desire Tshala-Katumbay et al.

Toxicological sciences : an official journal of the Society of Toxicology, 107(2), 482-489 (2008-11-27)

Neuroprotein changes in the spinal cord of rodents with aliphatic gamma-diketone axonopathy induced by 2,5-hexanedione (2,5-HD) are compared with those reported previously in aromatic gamma-diketone-like axonopathy induced by 1,2-diacetylbenzene (1,2-DAB). Sprague-Dawley rats were treated intraperitoneally with 500 mg/kg/day 2,5-HD, equimolar

Organic solvent metabolite, 1,2-diacetylbenzene, impairs neural progenitor cells and hippocampal neurogenesis.

Min-Sun Kim et al.

Chemico-biological interactions, 194(2-3), 139-147 (2011-10-25)

1,2-Diacetylbenzene (DAB) is a neurotoxic minor metabolite of 1,2-diethylbenzene or naphthalene reaction product with OH radical. DAB causes central and peripheral neuropathies that lead to motor neuronal deficits. However, the potent effects and molecular mechanisms of DAB on neural progenitor

Environmental metabolite, 1,2-diacetylbenzene, produces cytotoxicity through ROS generation in HUVEC cells.

Min Kyeong Kim et al.

Journal of toxicology and environmental health. Part A, 70(15-16), 1336-1343 (2007-07-27)

Organic solvents are ubiquitous in industrial and household surroundings, and thus individuals are easily exposed. 1,2-Diethylbenzene (DEB) is one of organic solvents contained in gasoline or jet fuels. DEB is absorbed by dermal or inhalation routes, metabolized by cytochrome P-450

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Global Trade Item Number

SKU	GTIN
242039-100MG	04061831819229
242039-500MG	04061831819236