244007
3,3,5,5-Tetramethyl-1-pyrroline N-oxide
95%
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About This Item
Empirical Formula (Hill Notation):
C8H15NO
CAS Number:
Molecular Weight:
141.21
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Assay
95%
form
solid
bp
73 °C/1 mmHg (lit.)
mp
58-61 °C (lit.)
storage temp.
−20°C
SMILES string
CC1(C)CC(C)(C)[N+]([O-])=C1
InChI
1S/C8H15NO/c1-7(2)5-8(3,4)9(10)6-7/h6H,5H2,1-4H3
InChI key
GUQARRULARNYQZ-UHFFFAOYSA-N
General description
The ESR spectrum of 3,3,5,5-tetramethyl-1-pyrroline N-oxide was studied.
Application
3,3,5,5-Tetramethyl-1-pyrroline N-oxide was used as a spin traping reagent.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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S Unchern et al.
Neurochemical research, 23(1), 97-102 (1998-03-03)
We compared neurotoxicity of piperine and low K+ on cultured cerebellar granule neurons. As considered from lactate dehydrogenase release and 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide reduction, both piperine and shifting from high K+ (25 mM) to low K+ (5.4 mM) were
G M Rosen et al.
Journal of medicinal chemistry, 31(2), 428-432 (1988-02-01)
Two nitrones, 3,3-diethyl-5,5-dimethylpyrroline 1-oxide (DEDMPO) and 3,3,5,5-tetramethylpyrroline 1-oxide (M4PO), were synthesized by the zinc/ammonium chloride reduction of appropiately substituted gamma-nitrocarbonyl compounds, followed by addition of methylmagnesium bromide to the resulting intermediate nitrones. The lipophilicities of these nitrones were estimated by
T Ozawa et al.
Free radical biology & medicine, 20(6), 837-841 (1996-01-01)
The reactivities of the chlorine dioxide (ClO2), which is a stable free radical towards some water-soluble spin-traps were investigated in aqueous solutions by an electron spin resonance (ESR) spectroscopy. The ClO2 radical was generated from the redox reaction of Ti3+
H Mori et al.
Biochemistry and molecular biology international, 32(3), 523-529 (1994-03-01)
To determine whether hydroxyl radicals (.OH) are generated in the hypoxanthine (HPX)-xanthine oxidase (XOD) reaction, we examined the electron paramagnetic resonance (EPR) spectra of the spin adducts formed. In the EPR study, we used 3,3,5,5-tetramethyl-1-pyrroline-N-oxide (M4PO) as a spin trap
C M Arroyo et al.
Free radical research communications, 9(3-6), 287-296 (1990-01-01)
Endothelial cells were subjected to anoxia/reoxygenation in order to simulate some of the free radical mechanisms occurring in ischaemia/reperfusion. With ESR and spin trapping using the spin traps 5,5-dimethyl-1-pyrroline-1-oxide (DMPO) and 3,3,5,5-dimethyl-1-pyrroline-1-oxide (M4PO), the results show that upon reoxygenation of
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