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244309

Ethyl β-carboline-3-carboxylate

Name: Ethyl β-carboline-3-carboxylate
Brand: ALDRICH

97%

Synonym(s):

β-CCE, Ethyl 9H-pyrido[3,4-b]indole-3-carboxylate

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₂N₂O₂

CAS Number:

74214-62-3

Molecular Weight:

240.26

NACRES:

NA.22

PubChem Substance ID:

24854665

UNSPSC Code:

12352100

MDL number:

MFCD00009730

Assay:

97%

Form:

solid

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Properties

assay

97%

form

solid

mp

228-230 °C (lit.)

functional group

ester

SMILES string

CCOC(=O)c1cc2c(cn1)[nH]c3ccccc23

InChI

1S/C14H12N2O2/c1-2-18-14(17)12-7-10-9-5-3-4-6-11(9)16-13(10)8-15-12/h3-8,16H,2H2,1H3

InChI key

KOVRZNUMIKACTB-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA5(2558), GABRG2(2566)
rat ... Gabra2(29706)

Description

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Benzodiazepines induce a conformational change in the region of the gamma-aminobutyric acid type A receptor alpha(1)-subunit M3 membrane-spanning segment.

D B Williams et al.

Molecular pharmacology, 58(5), 1129-1136 (2000-10-20)

Benzodiazepine binding to gamma-aminobutyric acid type A (GABA(A)) receptors allosterically modulates GABA binding and increases the currents induced by submaximal GABA concentrations. Benzodiazepines induce conformational changes in the GABA-binding site in the extracellular domain, but it is uncertain whether these

Benzodiazepine inverse agonists augment long-term potentiation in CA1 and CA3 of guinea pig hippocampal slices.

M Yasui et al.

Neuropharmacology, 32(2), 127-131 (1993-02-01)

The effects of benzodiazepine inverse agonists on the long-term potentiation of synaptic transmission in hippocampal slices of the guinea pig were examined using an extracellular recording technique. Benzodiazepine inverse agonists, beta-carboline-3-carboxylate (beta-CCE), 2-phenylpyrazolo [4,3-c]quinolin-3(5H)-one (CGS-8216) and 2-[5-methylthien-3-yl]-2,5-dihydro-3H-pyrazolo [4,3-c]quinolin-3-one (S-135), augmented

Effects of beta-carboline on fear-related behavioral and neurohormonal responses in infant rhesus monkeys.

N H Kalin et al.

Biological psychiatry, 31(10), 1008-1019 (1992-05-15)

We examined the effects of the inverse benzodiazepine agonist ethyl-beta-carboline-3-carboxylate (beta-CCE) on behavioral, hormonal, and neurochemical responses in infant rhesus monkeys exposed to fearful situations. Our paradigm elicits three distinct adaptive patterns of defensive behavior. From previous work, we hypothesized

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Global Trade Item Number

SKU	GTIN
244309-1G	04061826671368