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Merck
CN

244309

Ethyl β-carboline-3-carboxylate

97%

Synonym(s):

β-CCE, Ethyl 9H-pyrido[3,4-b]indole-3-carboxylate

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About This Item

Empirical Formula (Hill Notation):
C14H12N2O2
CAS Number:
74214-62-3
Molecular Weight:
240.26
NACRES:
NA.22
PubChem Substance ID:
24854665
UNSPSC Code:
12352100
MDL number:
MFCD00009730
Assay:
97%
Form:
solid

Key Documents

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InChI

1S/C14H12N2O2/c1-2-18-14(17)12-7-10-9-5-3-4-6-11(9)16-13(10)8-15-12/h3-8,16H,2H2,1H3

SMILES string

CCOC(=O)c1cc2c(cn1)[nH]c3ccccc23

InChI key

KOVRZNUMIKACTB-UHFFFAOYSA-N

assay

97%

form

solid

mp

228-230 °C (lit.)

functional group

ester

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA5(2558), GABRG2(2566)
rat ... Gabra2(29706)

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKBV6762V
MKBN4714V
MKBH6160V
MKBB4707V
MKBB4707

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D B Williams et al.
Molecular pharmacology, 58(5), 1129-1136 (2000-10-20)
Benzodiazepine binding to gamma-aminobutyric acid type A (GABA(A)) receptors allosterically modulates GABA binding and increases the currents induced by submaximal GABA concentrations. Benzodiazepines induce conformational changes in the GABA-binding site in the extracellular domain, but it is uncertain whether these
M Yasui et al.
Neuropharmacology, 32(2), 127-131 (1993-02-01)
The effects of benzodiazepine inverse agonists on the long-term potentiation of synaptic transmission in hippocampal slices of the guinea pig were examined using an extracellular recording technique. Benzodiazepine inverse agonists, beta-carboline-3-carboxylate (beta-CCE), 2-phenylpyrazolo [4,3-c]quinolin-3(5H)-one (CGS-8216) and 2-[5-methylthien-3-yl]-2,5-dihydro-3H-pyrazolo [4,3-c]quinolin-3-one (S-135), augmented
N H Kalin et al.
Biological psychiatry, 31(10), 1008-1019 (1992-05-15)
We examined the effects of the inverse benzodiazepine agonist ethyl-beta-carboline-3-carboxylate (beta-CCE) on behavioral, hormonal, and neurochemical responses in infant rhesus monkeys exposed to fearful situations. Our paradigm elicits three distinct adaptive patterns of defensive behavior. From previous work, we hypothesized
Beta-carboline-3-carboxylic acid ethyl ester: a lead for new psychotropic drugs.
R Schmiechen et al.
Psychopharmacology series, 11, 7-15 (1993-01-01)
L R Gerak et al.
Pharmacology, biochemistry, and behavior, 61(4), 375-380 (1998-11-05)
This study examined changes in ventilation produced by negative gamma-aminobutyric acid(A) (GABA(A)) modulators in rhesus monkeys. The effects of Ro 15-4513, beta-CCE and beta-CCM were examined in four rhesus monkeys breathing air or 5% CO2 in air. When monkeys breathed
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