246565
2-Pyridylacetonitrile
99%
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About This Item
Empirical Formula (Hill Notation):
C7H6N2
CAS Number:
Molecular Weight:
118.14
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
220-364-6
Beilstein/REAXYS Number:
111215
MDL number:
Assay:
99%
assay
99%
refractive index
n20/D 1.525 (lit.)
bp
76-77 °C/2 mmHg (lit.)
density
1.059 g/mL at 25 °C (lit.)
SMILES string
N#CCc1ccccn1
InChI
1S/C7H6N2/c8-5-4-7-3-1-2-6-9-7/h1-3,6H,4H2
InChI key
UKVQBONVSSLJBB-UHFFFAOYSA-N
General description
2-Pyridylacetonitrile undergoes coupling with aromatic diazonium salts to yield arylhydrazones. It also undergoes condensation with active malonic esters to yield 1-cyano-3-substituted 2-hydroxyquinolizin-4-ones. Acylation reaction of 2-pyridylacetonitrile with hot acetic anhydride has been reported.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
201.2 °F - closed cup
flash_point_c
94 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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F S Soliman et al.
Die Pharmazie, 32(5), 278-279 (1977-05-01)
Active malonic esters condense with 2-pyridylacetonitrile giving 1-cyano-3-substituted 2-hydroxyquinolizin-4-ones. Catalytic hydrogenation of the resulting products led to the corresponding 1-cyano-3-substituted-2-hydroxy-6.7.8.9-tetrahydroquinolizin-4-ones. On the other hand, condensation of the active malonic esters with beta-aminocrotononitrile afforded 5-cyano-3-substituted-4-hydroxy-6-methylpyridine-2-ones. The IR and NMR data are
Mariam Abdullah Al-Sheikh et al.
Molecules (Basel, Switzerland), 14(11), 4406-4413 (2009-11-20)
2-Pyridylacetonitrile (1) couples with aromatic diazonium salts to yield arylhydrazones 2a-c, that were shown to exist in the syn-form 2 rather than the anti-form 4. Compounds 2a,c reacted with hydroxylamine in refluxing DMF to yield the interesting 1,2,3-triazolylpyridines 6. Attempts
Acylation and other reactions of 2-and 4-pyridylacetonitrile.
Gutsche CD and Voges HD.
The Journal of Organic Chemistry, 32(9), 2685-2689 (1969)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 246565-100G | 04061837663055 |
| 246565-5G | 04061837663062 |
| 246565-25G | 04061825866307 |