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247979

1-Bromo-2,4,5-trifluorobenzene

99%

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About This Item

Linear Formula:
BrC6H2F3
CAS Number:
327-52-6
Molecular Weight:
210.98
NACRES:
NA.22
PubChem Substance ID:
24854904
UNSPSC Code:
12352100
EC Number:
206-318-8
MDL number:
MFCD00000306
Assay:
99%
Form:
liquid
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Quality Level

100

assay

99%

form

liquid

refractive index

n20/D 1.485 (lit.)

bp

144 °C (lit.)

mp

−19 °C (lit.)

solubility

water: insoluble

density

1.802 g/mL at 25 °C (lit.)

functional group

bromo, fluoro

SMILES string

Fc1cc(F)c(Br)cc1F

InChI

1S/C6H2BrF3/c7-3-1-5(9)6(10)2-4(3)8/h1-2H

InChI key

DVTULTINXNWGJY-UHFFFAOYSA-N

General description

1-Bromo-2,4,5-trifluorobenzene undergoes Br-Mg-exchange reaction with i-PrMgBr in THF to yield organomagnesium compound.

Application

1-Bromo-2,4,5-trifluorobenzene has been used in the synthesis of:
  • 3-ethenyl, 3-ethynyl, 3-aryl and 3-cyclopropyl-2,4,5-trifluorobenzoic acids
  • 3-bromo-2,5,6-trifluorobenzoic acid and 2,4,5-trifluorobenzoic acid

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

132.8 °F - closed cup

flash_point_c

56 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKCD7398
MKCD5005
MKCD4322
MKBL2545V
MKBB4886V

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3-Ethenyl, 3-ethynyl, 3-aryl, and 3-cyclopropyl-2, 4, 5-trifluorobenzoic acids: Useful intermediate in the synthesis of quinolone antibacterials.
Turner WR and Suto MJ.
Tetrahedron Letters, 34(2), 281-284 (1993)
Bromine-magnesium-exchange as a general tool for the preparation of polyfunctional aryl and heteroaryl magnesium-reagents.
Abarbri M, et al.
Tetrahedron Letters, 40(42), 281-284 (1999)
A dramatic solvent effect during aromatic halogen-metal exchanges. Different products from lithiation of polyfluorobromobenzenes in ether and tetrahydrofuran.
Bridges AJ, et al.
The Journal of Organic Chemistry, 55(2), 773-775 (1990)
View All Related Papers

Global Trade Item Number

SKUGTIN
247979-5G04061837071898