250279
3-(Trifluoromethyl)benzoyl chloride
98%
Synonym(s):
α,α,α-Trifluoro-m-toluoyl chloride
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About This Item
Linear Formula:
CF3C6H4COCl
CAS Number:
Molecular Weight:
208.56
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
218-844-5
Beilstein/REAXYS Number:
391266
MDL number:
Assay:
98%
Form:
liquid
InChI key
RUJYJCANMOTJMO-UHFFFAOYSA-N
InChI
1S/C8H4ClF3O/c9-7(13)5-2-1-3-6(4-5)8(10,11)12/h1-4H
SMILES string
FC(F)(F)c1cccc(c1)C(Cl)=O
assay
98%
form
liquid
Quality Level
refractive index
n20/D 1.477 (lit.)
bp
184-186 °C/750 mmHg (lit.)
density
1.383 g/mL at 25 °C (lit.)
functional group
acyl chloride, fluoro
Related Categories
Application
3-(Trifluoromethyl)benzoyl chloride has been used in the preparation of intermediates, required for synthesis of C-2 and C-3 substituted pyrazolo[1,5-a]pyrimidines.
signalword
Danger
hcodes
Hazard Classifications
Skin Corr. 1B
Storage Class
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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Dan M Berger et al.
Bioorganic & medicinal chemistry letters, 19(23), 6519-6523 (2009-10-30)
As part of our research effort to discover B-Raf kinase inhibitors, we prepared a series of C-3 substituted N-(3-(pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamides. X-ray crystallography studies revealed that one of the more potent inhibitors (10n) bound to B-Raf kinase without forming a hinge-binding hydrogen
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