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Merck
CN

252999

Nialamide

95%

Synonym(s):

N-Benzyl-β-(isonicotinylhydrazino)propionamide, N-Isonicotinoyl-N′-[β-(N-benzylcarboxamido)ethyl]hydrazine, Pyridine-4-carboxylic 2-[2-(benzylcarbamoyl)ethyl]hydrazide

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About This Item

Empirical Formula (Hill Notation):
C16H18N4O2
CAS Number:
51-12-7
Molecular Weight:
298.34
EC Number:
200-079-3
UNSPSC Code:
12352100
PubChem Substance ID:
24855254
Beilstein/REAXYS Number:
492941
MDL number:
MFCD00010106
Assay:
95%

Key Documents

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InChI key

NOIIUHRQUVNIDD-UHFFFAOYSA-N

InChI

1S/C16H18N4O2/c21-15(18-12-13-4-2-1-3-5-13)8-11-19-20-16(22)14-6-9-17-10-7-14/h1-7,9-10,19H,8,11-12H2,(H,18,21)(H,20,22)

SMILES string

O=C(CCNNC(=O)c1ccncc1)NCc2ccccc2

assay

95%

mp

152-154 °C (lit.)

solubility

methanol: soluble 10 mg/mL, clear, colorless to faintly yellow

functional group

amide, amine, hydrazide, phenyl

Gene Information

human ... MAOA(4128), MAOB(4129)

General description

Nialamide is an antidepressant drug and its effect on β-adrenergic receptor-adenylate cyclase system of rat pineal gland has been studied. Antidepressant action of the combination of nialamide and 5-hydroxytryptophan has been evaluated.

Biochem/physiol Actions

Non-selective MAO-A/B inhibitor.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKBB4405V
MKBB4405
10218TW
14621LG

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[Modulation of transcranial electroanalgesia by effecting the serotoninergic system of the brain].
A B Savchenko et al.
Doklady Akademii nauk, 347(2), 275-277 (1996-03-01)
T Karhula et al.
Neuroscience letters, 194(1-2), 85-88 (1995-07-14)
Localization of 5-hydroxytryptamine immunoreactivity was studied in the rat coeliac-superior mesenteric ganglion complex and in the porcine superior and inferior mesenteric ganglia by the indirect immunofluorescence technique. In normal rats, only 5-hydroxytryptamine immunoreactive SIF cells were seen in the coeliac-superior
Jason A Nieuwsma et al.
Annals of internal medicine, 167(10), 725-735 (2017-11-14)
Patients who have had an acute coronary syndrome (ACS) event have an increased risk for depression. To evaluate the diagnostic accuracy of depression screening instruments and to compare safety and effectiveness of depression treatments in adults within 3 months of
H Leblond et al.
The Journal of physiology, 525 Pt 1, 225-240 (2000-05-16)
Intracellular recording of lumbosacral motoneurones in the decerebrate and partially spinalized cat injected with nialamide and L-dihydroxyphenylalanine (l-DOPA) was used to investigate the interneuronal convergence of two bulbospinal pathways and of the segmental pathways involved with the generation of extensor
J J Aliño et al.
International pharmacopsychiatry, 11(1), 8-15 (1976-01-01)
Through a controlled double-blind study in 30 hospitalized patients affected with endogenous depression, the antidepressant action of the combination of nialamide+l-5-HTP has been evaluated and compared with a control group which only received nialamide (+ placebo). The patients treated with
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