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258881

Sigma-Aldrich

2-Amino-1,3,4-thiadiazole

97%

Synonym(s):

1,3,4-Thiadiazol-2-amine

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5 G
¥169.76

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Estimated to ship on2025年7月30日Details


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5 G
¥169.76

About This Item

Empirical Formula (Hill Notation):
C2H3N3S
CAS Number:
Molecular Weight:
101.13
Beilstein:
107135
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

¥169.76


Estimated to ship on2025年7月30日Details


Request a Bulk Order

Quality Level

Assay

97%

form

powder

mp

188-191 °C (dec.) (lit.)

solubility

water: soluble 25 mg/mL, clear, colorless

SMILES string

Nc1nncs1

InChI

1S/C2H3N3S/c3-2-5-4-1-6-2/h1H,(H2,3,5)

InChI key

QUKGLNCXGVWCJX-UHFFFAOYSA-N

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This Item
494216127906464627
assay

97%

assay

99%

assay

95%

assay

97%

solubility

water: soluble 25 mg/mL, clear, colorless

solubility

-

solubility

-

solubility

-

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

-

mp

188-191 °C (dec.) (lit.)

mp

178-181 °C (lit.)

mp

235 °C (dec.) (lit.)

mp

200 °C (dec.) (lit.)

form

powder

form

-

form

-

form

-

General description

2-Amino-1,3,4-thiadiazole (donor) form charge transfer complexes with 2,3-dichloro-5,6-dicyano-p-benzoquinone, p-chloranil, o-chloranil, p-bromanil and chloranilic acid (acceptors)[1]. Effects of 2-amino-1,3,4-thiadiazole [aminothiadiazole (NSC 4728)] on purine and pyrimidine ribonucleotide pools of L1210 ascites cells in vivo has been reported[2].

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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R Asbury et al.
American journal of clinical oncology, 19(4), 400-402 (1996-08-01)
Aminothiadiazole (NSC 4728) is an analog of the thiadiazoles, a group of drugs that stimulated interest because they do not cause significant myelosuppression and have a unique ability to increase uric acid production unrelated to tissue damage. Previous articles have
P F Engstrom et al.
American journal of clinical oncology, 14(1), 33-35 (1991-02-01)
Twenty-three patients with advanced inoperable squamous cell carcinoma of the esophagus were treated with aminothiadiazole (A-TD) 125 mg/m2 weekly plus allopurinol daily in a phase II cooperative group trial. No patients responded to treatment; 17 patients progressed, three showed stable
Palraj Kalimuthu et al.
Bioelectrochemistry (Amsterdam, Netherlands), 79(2), 168-172 (2010-04-23)
We report the selective determination of homocysteine (HCY) in the presence of one of the very important interferents, ascorbic acid (AA) using electropolymerized film of 2-amino-1,3,4-thiadiazole (ATD) modified glassy carbon electrode (GCE) at physiological pH for the first time. An
Andrea Cuconati et al.
PloS one, 8(1), e54595-e54595 (2013-01-29)
Hepatocellular carcinoma (HCC) is the third most common cause of cancer fatalities worldwide, with limited treatment options and five year survival rates of between <5 and 15%. To address this medical need, we conducted a screen of a drug-like small
G Y Locker et al.
Cancer treatment reports, 71(6), 649-650 (1987-06-01)
Eighty-three patients with advanced colorectal carcinoma were entered on a phase II trial of weekly iv aminothiadiazole (125 mg/m2) plus daily oral allopurinol (300 mg). There were five partial responses. Median survival of all patients on study was 36 weeks

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